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Single photon emission computerized tomography in childhood hydrocephalus

Abstract

Single photon emission computerized tomography (SPECT) is now widely used as one of the tools in evaluating cerebral blood flow (CBF). The authors report the CBF changes in childhood hydrocephalus. Five pediatric cases studied by 123I-IM SPECT in children are presented. The authors counted radioactivities both in early and delayed images in each patient, and calculated the reabsorption ratio (RR). Two negative-RR cases and three positive-RR cases were found. All of the negative-RR patients had a poor prognosis, while all of the positive-RR patients had a favorable outcome.

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References

  1. De SN (1950) A study of the changes in the brain in experimental internal hydrocephalus. J Pathol Bacteriol 62: 197–208

    Google Scholar 

  2. Defer G, Moretti JL, Cesaro P, Sergent A, Raynaud C, Degos JD (1982) Early and delayed SPECT using N-isopropyl-p-iodoamphetamine iodine 123 in cerebral ischemia. A prognostic index for clinical recovery. Arch Neurol 44: 715–718

    Google Scholar 

  3. Fukuda T, Ohtsubo Y, Hasue M, Akimoto J, Nishioka H, Miwa T (1990) Analysis of cerebral circulation and metabolic disturbance in head injury by 123I-IMP SPECT (in Japanese). Neurotraumatology 13: 115–121

    Google Scholar 

  4. Hill A, Volpe JJ (1982) Decrease in pulsatile flow in the anterior cerebral arteries in infantile hydrocephalus. Pediatrics 69: 4–7

    Google Scholar 

  5. Hino A, Takemoto S, Tenjin H, Imahori Y, Mizukawa N, Hirakawa K, Nakahashi H (1989) Hemodynamic and metabolic studies in patients with normal-pressure hydrocephalus using positron-emission tomography (in Japanese). Prog Comput Tomogr 11: 83–88

    Google Scholar 

  6. Kirkinen P, Muller R, Baumann H, Briner J, Lang W, Huch R, Huch A (1988) Cerebral blood flow velocity waveforms in hydrocephalic fetuses. J Clin Ultrasound 16: 493–498

    Google Scholar 

  7. Kohler C, Eriksson LG, Hansson T, Warner M, Ake-Gustafsson J (1988) Immunohistochemical localization of cytochrome p-450 in the rat brain. Neurosci Lett 84:109–114

    Google Scholar 

  8. Moretti JL, Holman BL, Delmon L, Carmel A, Johnson D, Moingeon P, Blau M (1987) Effect of antidepressant and narcoleptic drugs on N-isopropyl-p-iodoamphetamine biodistribution in animals. J Nucl Med 28: 354–359

    Google Scholar 

  9. Mori H, Shiba K, Matsuda H, Tsuji S, Hisada K (1990) Characteristics of the binding of N isopropyl-p-[125I]iodoamphetamine in the brain synaptosomal membranes. Nucl Med Commun 11: 327–331

    Google Scholar 

  10. Sato O, Ohya M, Nojiri K, Tsugane R (1985) Microcirculatory changes in experimental hydrocephalus: morphological and physiological studies. In: Shapiro K, Marmarou A, Portnoy H (eds) Hydrocephalus, Raven Press, New York, pp 215–230

    Google Scholar 

  11. Serlo W, Kirkinen P, Jouppilia P, Herva R (1986) Prognostic signs in fetal hydrocephalus. Child's Nerv Syst 2: 93–97

    Google Scholar 

  12. Weller RO, Shulman K (1972) Infantile hydrocephalus: clinical, histological, and ultrastructural study of brain damage. J Neurosurg 36: 255–265

    Google Scholar 

  13. Wladimiroff J, Tonge H, Stewart P, et al (1986) Severe intrauterine growth retardation: assessment of its origin from fetal arterial flow velocity waveforms. Eur J Obstet Gynecol Reprod Biol 22: 23–28

    Google Scholar 

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Shinoda, M., Yamaguchi, T., Tanaka, Y. et al. Single photon emission computerized tomography in childhood hydrocephalus. Child's Nerv Syst 8, 219–221 (1992). https://doi.org/10.1007/BF00262851

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  • DOI: https://doi.org/10.1007/BF00262851

Key words

  • Single photon emission computerized tomography (SPECT)
  • Childhood hydrocephalus
  • N-isopropyl-p-iodo-methylamphetamine (123I-IMP)
  • Early image
  • Delayed image