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Positive direct antiglobulin test in a pediatric patient following high-dose cisplatin

  • Original Articles
  • Cisdiamminedichloro-Platinum, Hemolytic Anaemia
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Summary

A positive direct antiglobulin test (DAT) and hemolitic anemia are uncommon side effect of cisplatin (CDDP) therapy. A 9-year-old girl treated for extraosseus Ewing's sarcoma with a multiagent regimen, including 200 mg/m2 CDDP preceded by vincristine (VCR) and cyclophosphamide (CY), developed a posititve DAT, followed by hemolitic anemia. When CDDP therapy was discontinued, the DAT became negative and no signs of anemia were observed during the maintenance treatment, which included VCR and actinomycin D.

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Authors and Affiliations

  1. Blood Bank “Giannina Gaslini” Children's Hospital, Genova, Italy

    G. Cinollo, E. Franchini & F. Sindaco

  2. Department of Pediatric Hematology/Oncology, “Giannina Gaslini” Children's Hospital, Genova, Italy

    G. Dini, E. Lanino & A. Garaventa

Authors
  1. G. Cinollo
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  2. G. Dini
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  3. E. Franchini
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  4. E. Lanino
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  5. F. Sindaco
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  6. A. Garaventa
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Cinollo, G., Dini, G., Franchini, E. et al. Positive direct antiglobulin test in a pediatric patient following high-dose cisplatin. Cancer Chemother. Pharmacol. 21, 85–86 (1988). https://doi.org/10.1007/BF00262747

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  • DOI: https://doi.org/10.1007/BF00262747

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