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Measurement of the risk of calcium oxalate crystallization in urine

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The risk of calcium crystallization (CaOx-CR) in urine was analyzed by means of crystal counting following standardized addition of oxalate. CaOx-CR was determined in 24h urine samples from 21 stone formers and 26 normal subjects following dilution of urine to a creatinine concentration of 5 μmol per ml. The mean (±SD) CaOx-CR was in stone formers 1.42±0.57 and in normal subjects 1.29±0.40. CaOx-CR was also analyzed in 16 fresh urine samples diluted to 80 per cent of the original concentration whereby values between 0.36 and 3.6 were recorded. There was a good correlation between CaOx-CR and estimates of the ion-activity product of CaOx, both in urine diluted to 5 μmol of creatinine per ml and in 80 per cent diluted urine. It ist suggested that the method described is of value for evalution and follow up of patients with CaOx urolithiasis.

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Tiselius, HG. Measurement of the risk of calcium oxalate crystallization in urine. Urol. Res. 13, 297–300 (1985). https://doi.org/10.1007/BF00262660

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