Summary
The effects of steroids (testosterone, dihydrotestosterone and estradiol) on human seminiferous tubules in vitro were ascertained by recording the intratubular pressure with a servonull micropressure measuring device. We describe here the first response of the human seminiferous tubule to steroids. Testosterone and dihydrotestosterone had a biphasic effect on tubular contractility. Higher doses of both testosterone and dihydrotestosterone induced contractions of the seminiferous tubules whereas lower doses of these compounds induced relaxation. Estradiol (10-9 M to 10-6 M) induced relaxation of the seminiferous tubules in a dose-dependent manner. The results from these experiments suggested that steroids may be involved in the control of contraction of the human seminiferous tubule and may regulate the movement of spermatozoa from the tests.
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References
Miyake K, Yamamoto M, Narita H, Hashimoto J, Mitsuya H (1986) Evidence for contractility of the human seminiferous tubule confirmed by its response to noradrenaline and acetylcholine. Fertil Steril 46:734–737
Roosen-Runge EC (1951) Motions of the seminiferous tubules of rat and dog. Anat Rec 109:413
Ross MH, Long IR (1966) Contractile cells in human seminiferous tubules. Science 153:1271–1273
Bressler RS, Ross MH (1972) Differentiation of peritubular myoid cells of the testis, effects of intratesticular implantation of newborn mouse testes into normal and hypophysectomized adults. Biol Reprod 6:148–159
Hovatta O (1972) Effect of androgens and antiandrogens on the development of the myoid cells of the rat seminiferous tubules (organ culture). Z Zellforsch Mikrosk Anat 131:299–308
Bressler RS, Ross MH (1969) Pituitary involvement in testicular peritubular cell maturation. Anat Rec 163:158–159
Kormano M, Hovatta O (1972) Contractility and histochemistry of the myoid cell layer of the rat seminiferous tubules during postnatal development. Z Anat Entwicklungsgesch 137:239–248
Smith G (1962) The effects of ligation on the vasa efferentia and vasectomy on testicular function in the adult rat. J Endocrinol 23:385–399
Davis JR, Langford GA (1969) Response of the testicular capsule to acetylcholine and noradrenaline. Nature 222:386–387
Niemi M, Kormano M (1965) Contractility of the seminiferous tubule of the postnatal rat testis and its response to oxytocin. Ann Med Wxp Biol Fenn 43:40–42
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Yamamoto, M., Nagai, T., Takaba, H. et al. In-vitro contractility of human seminiferous tubules in response to testosterone, dihydrotestosterone and estradiol. Urol. Res. 17, 265–268 (1989). https://doi.org/10.1007/BF00262608
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DOI: https://doi.org/10.1007/BF00262608