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Intratumoral measurement and plasma pharmacokinetics of intravenously administered Melphalan

Report of a patient with plasmacytoma

  • Original Articles
  • Plasma Pharmacokinetics, Chemotherapy, Melphalan, Plasmacytoma
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Summary

In a human case of plasmacytoma we studied plasma and tumor concentrations of melphalan given intravenously. Intratumoral concentration of melphalan was similar to plasma concentration 60 min after the end of infusion.

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References

  1. Adair CG, Bridges JM, Desai ZR (1986) Renal function in the elimination of oral melphalan in patients with multiple myeloma. Cancer Chemother Pharmacol 17: 185

    Google Scholar 

  2. Alberts DS, Chang SY, Chen H-SG, Moon TE, Evans TL, Furner RL, Himmelstein K, Gross JF (1979) Kinetics of intravenous melphalan. Clin Pharmacol Ther 26: 73

    Google Scholar 

  3. Barlogie B, Smith L, Alexanian R (1984) Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 310, 1353

    CAS  PubMed  Google Scholar 

  4. Brown RK, Duncan G, Hill DL (1980) Distribution and elimination of melphalan in rats and monkeys and distribution in tumors of mice bearing L 1210 or P 388 leukemias sensitive and resistant to this agent. Cancer Treat Rep 64: 643

    Google Scholar 

  5. Ehrsson H, Eksborg S, Lindfors A (1986) Quantitative determination of melphalan in plasma by liquid chromatography after derivatization with N-acetylcysteine. J Chromatogr 380: 222

    Google Scholar 

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Authors and Affiliations

  1. Department of General Oncology, Danderyd's Hospital, S-18288, Danderyd, Sweden

    Sten Friberg

  2. Karolinska Pharmacy, Box 60024, S-10401, Stockholm, Sweden

    Hans Ehrsson & Staffan Eksborg

  3. Department of Otorhinolaryngology, Karolinska Hospital, S-10401, Stockholm, Sweden

    Christer Carenfeldt

Authors
  1. Sten Friberg
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  2. Hans Ehrsson
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  3. Staffan Eksborg
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  4. Christer Carenfeldt
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Friberg, S., Ehrsson, H., Eksborg, S. et al. Intratumoral measurement and plasma pharmacokinetics of intravenously administered Melphalan. Cancer Chemother. Pharmacol. 20, 342–343 (1987). https://doi.org/10.1007/BF00262589

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  • DOI: https://doi.org/10.1007/BF00262589

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