Summary
Creatine kinase isoenzyme (CK-BB) measured by mass was used to determine its value in the early diagnosis of prostatic cancer. Sera of patients with prostatic carcinoma of various stages (treated and untreated) were compared to normal male sera and sera of patients with benign hyperplasia of the prostate (BPH) with respect to CK-BB. The sera were simultaneously tested for PAP content. The sensitivity of the CK-BB-RIA was 1.63+/-0.08 μg/l and reproducibility in the higher and lower concentration range 7.6% and 10.5%, respectively. CK-BB alone or in combination with PAP is no marker for early detection of prostatic cancer. In individual cases changes occurred similar to those found with a malignant growth of the prostate.
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Quininones GR, Rohner TJ, Drago JR, Demeres LM (1981) Will prostatic acid phosphatase determination by radioimmunoassay increase the diagnosis of early prostatic cancer? J Urol 125: 361
Roy AV, Brower ME, Hayden JE (1971) Sodium Thymolphthalein monophosphate. A new acid phosphate substrate with greater specificity for the prostatic enzyme in serum. Clin Chem 17:1093
Silverman LM, Dermer GB, Zweig MH, van Steirteghem AC, Tokes ZA (1979) Creatine kinase BB: A new tumor-associated marker. Clin Chem 25:1432
Jockers-Wretou E, Pfleiderer G (1975) Quantiation of CK-isoenzymes in human tissues and sera by an immunological method. Clin Chim Acta 58:223
Sjoevall K, Rubin S, Muentzing J (1975) CPK in prostatic tissue. Scand J Urol Nephrol 9:181
Hoag GN, Franks CR, Earle De Coteau W (1978) CK-isoenzymes in serum of patients with cancer of various organs. Clin Chem 24:1654
Lederer WH, Gerstbrein HL (1976) Creatine kinase isoenzyme BB activity in serum of a patient with gastric cancer. Clin Chem 22:1748
Coolen RB, Pragay DA, Nosanchuk JS, Belding R (1979) Elevation of brain type creatine kinase in serum from patients with carcinoma. Cancer 44:1414
Zweig MH, van Steirteghem AC (1979) Serum CK-Isoenzyme BB as an indicator of active metastatic disease. Clin Chem 25: 1190
Coolen RB (1976) The production of brain type Creatine kinase in the serum of patients with oat-cell carcinomas. Clin Chem 22:1174
Hoag G, Amies DR, Colquhoun BDP (1978) The production of Creatine kinase isoenzyme BB in sera of a patient with prostatic carcinoma and in tumor homogenates. Clin Biochem 11:38
Feld RD, Witte DL (1977) Presence of Creatine kinase BB isoenzyme in some patients with prostatic carcinoma. Clin Chem 23:1930
Fortman DT (1979) The significance of Creatine kinase (CK-BB) in metastatic cancer of the prostate. Ann Clin and Lab Sci 9:333
Feld RD, van Steirteghem AC, Zweig MH, Wimar GW, Narayana AS, Witte DL (1980) The presence of Creatine kinase BB isoenzyme in patients with prostatic cancer. Clin Chem Acta 100:267
Aleyassine H, MacIsaac SG (1980) The diagnostic significance of serum CK-BB isoenzyme in adenocarcinoma of prostate. Clin Biochem 13:109
Huber PR, Scholer A, Linder E, Hagmaier V, Vogt H, Wolf T, Christen P, Eppenberger U, Rutishauser G (submitted for publication 1981) Measurement of prostatic acid phosphatase (PAP) by RIA compared to the Thymolphthalein monophosphate based enzymatic test in serum and bone marrow. Clin Chem
Yuu H, Tagaki Y, Senju O, Hosoya J, Gomi K, Ishii T (1978) Creatine kinase isoenzyme of high relative molecular mass in serum of cancer patient. Clin Chem 24:2054
Urdal P, Landaas S (1979) Macro Creatine kinase BB in serum and some data on its prevalence. Clin Chem 25:461
Stein W, Bohner J (1979) Immunoglobulin-bound creatine kinase BB (“Macro CK”) in three patients with different diseases. Clin Chem 25:1513
Zweig MH, van Steirteghem AC Schechter AN (1978) Radio-immunoassay Creatine kinase isoenzymes in human serum: Isoenzyme BB. Clin Chem 24:422
Zweig MH, van Steirteghem AC (1981) Assessment by Radio-immunoassay serum creatine kinase BB as tumormarker: Studies in patients with various cancer and a comparison of CK-BB concentrations to prostate acid phosphatase concentrations. JNCI 66:859
Oehr P, Wustrow A, Derigs G, Borman R (1981) Evaluation and characterization of tumor-associated antigens by the inverse distribution function. Tumor Diagnostik 2:195
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Huber, P.R., Zaugg, T., Linder, E. et al. Creatine kinase isoenzyme (CK-BB) in combination to prostatic acid phosphatase measured by RIA in the diagnosis of prostatic cancer. Urol. Res. 10, 75–80 (1982). https://doi.org/10.1007/BF00262406
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DOI: https://doi.org/10.1007/BF00262406