Summary
Tumors and biopsies from visibly normal urothelium in 36 consecutive patients with transitional cell bladder carcinoma were analysed for histological pathology, DNA ploidy and ABH isoantigens. Tumor isoantigen deletion correlated strongly with malignant histology (p=0.016) and aneuploidy (p=0.005). In 4/12 patients with ABH isoantigens present on the tumor, and in 6/8 with isoantigens absent, isoantigen changes were found in normal looking urothelium, usually with normal histology and ploidy. It was concluded that the ABH isoantigen change was an early event in bladder carcinoma.
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Borgström E, Wahren B (1986) Clinical significance of ABH isoantigen deletion of urothelial cells in bladder carcinoma. Cancer 58:2428–2434
Coon JS, Weinstein RS, Summers JL (1982) Blood group precursor T-antigen expression in human urinary bladder carcinoma. Am J Clin Pathol 77:692–699
Coon JS, McCall A, Miller AW III, Farrow GM, Weinstein RS (1985) Expression of blood-group-related antigens in carcinoma in situ of the urinary bladder. Cancer 56:797–804
Davidsohn I (1972) Early immunologic diagnosis and prognosis of carcinoma. Am J Clin Pathol 57:715–730
Decenzo JM, Howard P, Irish CE (1975) Antigenic deletion and prognosis of patients with stage A transitional cell bladder carcinoma. J Urol 114:874–878
D'Elia FL, Cooper HS, Mulholland SG (1982) ABH isoantigens in stage 0 papillary transitional cell carcinoma of the bladder: correlation with biological behavior. J Urol 127:665–667
Farrow GM, Utz DC, Rife CC (1976) Morphological and clinical observations of patients with early bladder cancer treated with total cystectomy. Cancer Res 36:2495–2501
Giloh H, Sedat JW (1982) Fluroescence microscopy: reduced photobleaching of rhodamine and fluorescein protein conjugates by n-propyl gallate. Science 217:1252–1255
Hakomori S, Koscielak J, Bloch KJ, Jeanloz RW (1967) Immunologic relationship between blood group substances and a fucose-containing glycolipid of human adenocarcinoma. J Immunol 98:31–38
Koss LG (1979) Maaping of the urinary bladder: its impact on the concepts of bladder cancer. Hum Pathol 10:533–548
Lange PH, Limas C (1984) Molecular markers in the diagnosis and prognosis of bladder cancer. Urology [Suppl] 23:46–54
Limas C, Lange P (1980) Altered reactivity for A, B, H antigens in transitional cell carcinomas of the urinary bladder. A study of the mechanisms involved. Cancer 46:1366–1373
Stein BS, Reyes JM, Petersen RO, McNellis D, Dendall AR (1981) Specific red cell adherence: Immunologc evaluation of random muscosal biopsies in carcinoma of the bladder. J Urol 126:37–40
Stellner K, Hakomori S, Warner GA (1973) Enzymic conversion of “H1-glycolipid” to A or B-glycolipid and deficiency of these enzyme activities in adenocarcinoma. Biochem Biophys Res Commun 55:439–445
Tribukait B (1984) Flow cytometry in surgical pathology and cytology of tumors of the genito-urainry tract. In: Koss LG, Colemann DU (eds) Advances in clinical cytology, vol 2. Masson, USA, pp 163–189
Winstein RS, Alroy J, Farrow GM, Miller AM III, Davidsohn I (1979) Blood group isoantigen deletion in carcinoma in situ of the urinary bladder. Cancer 43:661–668
Weinstein RS, Miller AW III, Coon JS (1984) Tissue blood group ABH and Thomsen-Friedenreich antigens in human urinary bladder carcinoma. In: Progress and controversies in oncological urology. Alan R Liss, New York, pp 249–260
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Borgström, E., Nyman, C. & Lönn, M. ABH isoantigens, histology and DNA ploidy in 36 consecutive patients with transitional cell bladder cancer. Status of tumor and biopsies taken from visually normal urothelium. Urol. Res. 15, 199–202 (1987). https://doi.org/10.1007/BF00262099
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DOI: https://doi.org/10.1007/BF00262099