Summary
The influence of fluoride in drinking water on stone formation was studied in animals and in “in vitro” cristallization experiments. In male Wistar rats fluoride inhibits ethylenglycol induced calcification of the kidneys and stone formation. The in vitro results performed in synthetic urine exhibited a dose-dependent delay of cristal growth.
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References
Luoma H, Nuuja T, Collan Y, Nummikoski P (1976) The effect of magnesium and fluoride on nephrocalcinosis and aortic calcification in rats given high succrose diets with added phosphates. Calcif Tissue Res 20:291
Anasuya A (1982) Role of fluoride in formation of urinary calculi: Studies in rats. J Nutr 112:1787
Ljunghall S (1978) Regional variations in the incidence of urinary stones. Br Med J 18:439
Summers JL, Keitzer WA (1975) Effect of fluoridation on urinary tract calculi Ohio State Med J 71:25
Müller R, Hesse A, Schneider HJ (1978) Analytische Untersuchungen zur Bedeutung des Fluorgehalts in Harnsteinen. Kongrßband Jenaer Harnsteinsymposium, S 96 ff.
Hodgkinson A, Zarembski PM (1968) Oxalic acid metabolism in man: a review. Calcif Tissue Res 2:115
Wissenschaftliche Tabellen Geigy. Ciba-Geigy AG, Basel, 1977
Spira L (1972) Urinary calculi and fluorine. Exp Med Surg 14: 72
Herman JR, Papadakis L (1960) The relationship of sodium fluoride to nephrolithiasis in rats. J Urol 83:799
Hodgkinson A, Peacock M, Nickolson M (1969) Quantitative analysis of calcium containing urinary calculi. In: Hodgkinson A, Nordin BEC (eds) Renal stone research symposium Churchill, London
Zipkin J, Lee WA, Leone NC (1962) Fluoride content of urinary and biliary tract calculi. In: McClure FJ (ed) fluride drinking waters. Public Health Service Publ. No. 825,435, 1962, CU. S. Dep. HEW ((PHS)), Washington DC
Jolly SS, Sharma OP, Garg G, Sharma R (1980) Kidney changes and kidney, stones in endemic fluorosis. Fluoride 13:10
Hering F, Briellmann T, Seiler H, Rutishauser G (1984) Role of fluoride on stone formation. Plenum Press, New York (in press)
Meyer JL, Nancollas GH (1972) Effect of stannous and flouride ions on the rate of crystal, growth of hydroxyapatite. J Dent Res 51:1443
Finlayson B, Reid F (1978) The expectation of free and fixed particles in urinary stone. Invest Urol 15:442
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Hering, F., Briellmann, T., Seiler, H. et al. Fluoridation of drinking water: Effects on kidney stone formation. Urol. Res. 13, 175–178 (1985). https://doi.org/10.1007/BF00261819
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DOI: https://doi.org/10.1007/BF00261819