Summary
Medroxyprogesterone acetate (MAP) plasma pharmacokinetics was followed up in a total of 30 New Zealand rabbits after i. v. administration (0.1, 0.5, and 1.0 mg/kg) of either an aqueous suspension or a homogeneous solution of the drug in dimethylsulphoxide (DMSO). A well-defined triphasic decay of MAP plasma levels was noticeable in the animals treated with DMSO solutions. A delayed concentration peak was often present when aqueous suspensions were used, so if is not feasible to fit the experiment with simple polyexponential equations. Model-independent pharmacokinetic analysis (statistical moment theory) revealed a significant dependence of plasma clearance and mean residence time on the dose administered in both conditions.
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Supported in part by contract CNR, No. 85.02282.44 (Progetto finalizzato “Oncologia”)
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Pannuti, F., Camaggi, C.M., Strocchi, E. et al. Medroxyprogesterone acetate plasma pharmacokinetics after intravenous administration in rabbits. Cancer Chemother. Pharmacol. 19, 311–314 (1987). https://doi.org/10.1007/BF00261479
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DOI: https://doi.org/10.1007/BF00261479