Skip to main content

Advertisement

Log in

Modifying effect of commercially available stannous pyrophosphate (PYRO-Sn) on the tissue affinity of 99mTc pertechnetate

  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Investigations were performed to examine the conditions required for in vivo labelling of red blood cells (RBCs) with 99mTc after injection of stannous pyrophosphate. It was found that good in vivo labelling of RBCs is possible and that the efficacy of this procedure is high. The highest concentration of 99mTc in the blood occurred in the first 2 h after pertechnetate injection, and the optimum time between stannous pyrophosphate and pertechnetate injection ranged from 10 to 30 min.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Alderson, P.O., Bernier, D.R., Ludbrook, P.A., Harwig, J.F., Roberts, R., Sobel, B.E.: Serial radionuclide determinations of the ejection fraction with 99mTc-labeled red blood cells. Radiology 119, 729–730 (1976)

    Google Scholar 

  2. Atkins, H.L., Eckelman, W.C., Klopper, J.F., Richards, P.: Vascular imaging with 99mTc-red blood cells. Radiology 106, 357–360 (1973)

    Google Scholar 

  3. Bardy, A., Fonyé, H., Goblin, R., Beydon, J., Tovar, G. de, Pannecière, C., Hégésippe, M.: Techneitum-99m labeling by means of stannous pyrophosphate: Application to bleomycin and red blood cells. J. Nucl. Med. 16, 435–437 (1975)

    Google Scholar 

  4. Chandler, W.M., Shuck, L.D.: Abnormal technetium-99m pertechnetate imaging following stannous pyrophosphate bone imaging. J. Nucl. Med. 16, 518 (1975)

    Google Scholar 

  5. Fischer, T., Wolf, R., Leon, A.: Technetium-99m as a label for erythrocytes. J. Nucl. Med. 8, 229–232 (1967)

    Google Scholar 

  6. Hamilton, R.G., Alderson, P.O.: A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with 99mTc pertechnetate. J. Nucl. 18, 1008–1011 (1977)

    Google Scholar 

  7. Khentigan, A., Garret, M., Lum, D., Winchell, H.S.: Effects of prior administration of Sn/II/complexes on in vivo distribution of 99mTc-pertechnetate. J. Nucl. Med. 17, 380–384 (1976)

    Google Scholar 

  8. McRae, J., Sugar, R.M., Shipley, B., Hook, G.R.: Alterations in tissue distribution of 99mTc-pertechnetate in rats given stannous tin. J. Nucl. Med. 15, 151–155 (1974)

    Google Scholar 

  9. Pavel, D.G., Zimmer, A.M., Paterson, V.N.: In vivo labeling of red blood cells with 99mTc: A new approach to blood pool visualization. J. Nucl. Med. 18, 305–308 (1977)

    Google Scholar 

  10. Smith, T.D., Richards, P.: A simple kit for the preparation of 99mTc-labeled red blood cells. J. Nucl. Med. 17, 126–132 (1976)

    Google Scholar 

  11. Stokelý, E.M., Parkey, R.W., Bonte, F.J., Willerson, J.T.: Gated blood pool imaging following 99mTc stannous pyrophosphate imaging. Radiology 120, 433–434 (1976)

    Google Scholar 

  12. Zimmer, A.M.: In vitro technetium-99m red blood cell labeling using commercial stannous pyrophosphate. Am. J. Hosp. Pharm. 34, 264–267 (1977)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baltrukiewicz, Z., Przedlacki, J. & Dziuk, E. Modifying effect of commercially available stannous pyrophosphate (PYRO-Sn) on the tissue affinity of 99mTc pertechnetate. Eur. J. Nucl. Med. 5, 45–47 (1980). https://doi.org/10.1007/BF00261206

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00261206

Keywords

Navigation