Summary
The effects of stimulation with either 10 μmol/l norepinephrine or 85 mmol/l extracellular potassium concentration on calcium uptake were studied in muscle strips from human renal calyces and from the renal pelvis. The apparent uptake of calcium under control conditions was essentially complete after 30 min. Stimulation of the muscle strips with norephinephrine or high external potassium significantly (P<0.05) increased the calcium uptake over the control values at 30 and 100 min, whereas 45Ca efflux was virtually not affected. It is concluded that the mechanical responses of the muscle strips to norepinephrine or high external potassium correspond with an increased uptake of calcium suggesting that both types of activation are mediated by an increase of intracellular calcium concentration similar to that described in other smooth muscles.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Deth R, van Breemen C (1977) Agonist induced release of intracellular calcium in the rabbit aorta. J Membrane Biol 30:363–380
Deth RC (1978) Effect of lanthanum and reduced temperature on 45Ca efflux from rabbit aorta. Am J Physiol 234:C139-C145
Documenta Geigy (1968) In: Diem D, Lentner C (eds) Wissenschaftliche Tabellen, 7th edn. Geigy, Basel
Fleckenstein A (1977) Specific pharmacology of calcium in myocardium, cardiac pacemakers and vascular smooth muscle. Ann Rev Pharmacol Toxicol 17: 149–166
Godfraind T (1976) Calcium exchange in vascular smooth muscle, action of noradrenaline and lanthanum. J Physiol 260:21–35
Hertle L, Nawrath H (1984) Calcium channel blockade in smooth muscle of the human upper urinary tract. I. Effects on depolarization-induced activation. J Urol 132:1265–1269
Hertle, L, Nawrath H (1984) Calcium channel blockade in smooth muscle of the human upper urinary tract. II. Effects on norepinephrine-induced activation. J Urol 132:1270–1274
Lüllmann H (1970) Calcium fluxes and calcium destribution in smooth muscle. In: Bülbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle. Williams and Wilkins, Baltimore, pp 151–165
Meisheri KD, Hwang O, van Breemen C (1981) Evidence for two separate calcium pathways in smooth muscle plasmalemma. J Membrane Biol 59:19–25
Van Breemen C, Hwang O, Siegel B (1977) The lanthanum method. In: Casteels R, Godfraind T, Rüegg JC (eds) Excitation-contraction coupling in smooth muscle. Elsevier, Amsterdam, pp 243–253
Weiss GB (1977) Approaches to delineation of differing calcium binding sites in smooth muscle. In: Casteels R, Godfraind R, Rüegg JC (eds) Excitation-contraction coupling in smooth muscle. Elsevier, Amsterdam, pp 253–260
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hertle, L., Nawrath, H. Stimulation of calcium uptake by norepinephrine or high external potassium in human calyces and renal pelvis. Urol. Res. 17, 63–67 (1989). https://doi.org/10.1007/BF00261054
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00261054