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Über die Natur der durch Cobragift in durchströmten Meerschweinchenlungen freigesetzten „Slow Reacting Substance“

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Zusammenfassung

Es wurden Untersuchungen zur chemischen Natur der „slow reacting substance“ (SRS), die sich in der Durchströmungsflüssigkeit isolierter Meerschweinchenlungen und in Lungenextrakten nach Cobragifteinwirkung nachweisen läßt, angestellt.

Auf Grund der Löslichkeit, des Verhaltens bei Verteilung und Chromatographie und pharmakologischer Eigenschaften wird geschlossen, daß es sich bei der SRS um ungesättigte Fettsäuren handelt, die aus Gewebsphosphatiden durch die Cobragift-Phospholipase A abgespalten werden. Dieser Schluß wird dadurch bestätigt, daß gereinigte Bienengift-Phospholipase A ebenfalls SRS freisetzt.

Summary

The chemical nature of the „slow reacting substance“ (SRS) which appears in perfusates or extracts of guinea pig lung after injection of cobra venom has been investigated.

The solubility pattern of SRS, its behaviour in liquid-liquid distribution and in chromatography as well as its actions on smooth muscle indicate that SRS consists of pharmacologically active unsaturated fatty acids. These acids apparently derive from tissue phosphatides from which they are cleaved by the action of phospholipase A contained in cobra venom. This conclusion is confirmed by the finding that purified phospholipase A obtained from bee venom also liberates SRS.

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Authors and Affiliations

  1. Aus der Pharmakologischen Abteilung der Medizinischen Forschungsanstalt der Max Planck-Gesellschaft, Göttingen

    R. M. Schütz & W. Vogt

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  1. R. M. Schütz
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  2. W. Vogt
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Herrn Professor Dr. O. Schaumann zum 70. Geburtstag gewidmet.

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Schütz, R.M., Vogt, W. Über die Natur der durch Cobragift in durchströmten Meerschweinchenlungen freigesetzten „Slow Reacting Substance“. Naunyn - Schmiedebergs Arch 240, 504–513 (1961). https://doi.org/10.1007/BF00260271

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  • DOI: https://doi.org/10.1007/BF00260271

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