Summary
A coccidial infection initiates a stress reaction in chickens which results in catabolism. If a radioprotective chemical (5-hydroxytryptamine) was administered shortly before infection, the catabolic reaction failed to occur. Thus the lethal effect of otherwise fatal coccidial infections (Eimeria necatrix) was almost completely prevented. The body weight of the infected chickens was not significantly reduced by the infection. The stress reaction was not affected, if 5-hydroxytryptamine was applied after infection (2 hours, 1, 2, 3, 4 or 5 days p.i.). An effect of this chemical on the endogenous development of Eimeria necatrix was not observed.
It is concluded that death following a single inoculation of a large number of oocysts is due to an alarm reaction and not to a specific pathogenic action of the parasites.
Zusammenfassung
Eine Coccidieninfektion löst beim Huhn eine Stressreaktion aus. Der hierbei erfolgende katabole Stoffwechsel bleibt aus, wenn kurz vor der Infektion eine Strahlenschutzsubstanz (5-Hydroxy-tryptamin) verabreicht wird. Hierdurch wird der tödliche Ausgang einer letalen Coccidieninfektion in einem hohen Prozentsatz verhindert; die Infektion verläuft ohne wesentlichen Gewichts-verlust. Bei Verabreichung dieses Präparates nach der Infektion (2 Std, 1, 2, 3, 4 oder 5 Tage p.i.) läuft die Stressreaktion unbeeinflußt ab. Auf die endogene Entwicklung der Coccidien übt 5-Hydroxytryptamin keine Wirkung aus.
Der durch Verabreichen einer einmaligen hohen Oocystendosis verursachte Tod ist nicht durch die spezifische Coccidienwirkung, sondern durch die unspezifische Alarmreaktion bedingt.
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Schole, J., Dey-Hazra, A., Harisch, G. et al. Zur Pathogenität der Coccidien des Huhnes. Z. F. Parasitenkunde 38, 3–13 (1971). https://doi.org/10.1007/BF00259479
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DOI: https://doi.org/10.1007/BF00259479