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Aktivierung proteolytischer Fermente bei Entzündungsreaktionen

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Summary

  1. 1.

    Guinea pig serum profibrinolysin (plasminogen) is activated in vitro by dextran and ovomucoid.

  2. 2.

    In cat and rat serum, activation of proteolytic enzymes takes place neither by dextran or ovomucoid nor by streptokinase.

  3. 3.

    Incubating ricin with tissu extracts, it is possible under determined conditions to show an increased proteolytic activity.

  4. 4.

    From the results is concluded that the activation of a protease, active on theph range of 7,4 as trypsin or fibrinolysin, can not be the cause for the appearence of the dextran or ovomucoide dema of rats, but may have some fundamental meaning for the genesis of the ricin necrosis.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Freien Universität Berlin, Germany

    Martin Kramer

  2. Soc. Ital. Prodotti Schering, Via Mancinelli 7, Mailand, Italien

    Martin Kramer

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  1. Martin Kramer
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Additional information

Ein Teil der Ergebnisse wurde auf der 21. Tagung der Deutschen Pharmakologischen Gesellschaft in Saarbrücken vorgetragen.

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Kramer, M. Aktivierung proteolytischer Fermente bei Entzündungsreaktionen. Naunyn - Schmiedebergs Arch 234, 432–438 (1958). https://doi.org/10.1007/BF00258933

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  • DOI: https://doi.org/10.1007/BF00258933

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