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Relationship between experimentally induced crystalluria and relative supersaturation of various stone salts in rats

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Calcium oxalate crystalluria was induced in laboratory rats by subcutaneous implantation of potassium oxalate containing mini-osmotic pumps in their intercapsular region. Concentrations of major urinary ions were measured and urinary supersaturations of various urinary salts were calculated using a computer programme. The urines of experimental animals that received oxalate had calcium oxalate crystals and higher supersaturations for calcium oxalate compared to their controls. Oxalate levels of the urines of experimental animals were higher than their controls and this increase was proportional to the increase in urinary supersaturation of calcium oxalate. No significant difference was found in the calcium levels of urines from experimental and control animals.

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Khan, S.R., Thomas, W.C. & Hackett, R.L. Relationship between experimentally induced crystalluria and relative supersaturation of various stone salts in rats. Urol. Res. 12, 271–273 (1984).

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