Abstract
Organ distribution and tumor uptake of 57Co-bleomycin (BLM) were examined in NMRI mice without tumor and with chemically (DMBA-) induced squamous cell carcinoma. In these tumors high accumulation of 57Co-BLM was recorded shortly after injection of 57Co-BLM and low uptake 24–48 h after application. Two groups of tumor-bearing mice received unlabeled bleomycin as a cytostatic in two different doses. Uptake of 57Co-bleomycin was reduced.
The study suggests that in patients currently or previously under chemotherapy, 57Co-bleomycin tumor scintigraphy may lead to false negative results.
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This publication is part of the dissertation of G. Dieffenbach
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Pertynski, T., Reznik, G., Mariß, P. et al. The influence of chemotherapy on the distribution of 57Co-bleomycin in chemically induced squamous cell carcinoma of mouse skin. Eur J Nucl Med 4, 55–59 (1979). https://doi.org/10.1007/BF00257571
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DOI: https://doi.org/10.1007/BF00257571