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Hepatic intra-arterial infusion of vincristine

  • Original Articles
  • Vincristine, Hepatic Artery Infusion
  • Published:
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Summary

Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial.

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Authors and Affiliations

  1. Department of Medicine, Oncology Research Center, Bowman Gray School of Medicine, of Wake Forest University, 27103, Winston-Salem, NC, USA

    Don V. Jackson Jr., Frederick Richards II, Charles L. Spurr, Tony R. Long & Duff A. Rardin

  2. Department of Surgery, Oncology Research Center, Bowman Gray School of Medicine, of Wake Forest University, 27103, Winston-Salem, NC, USA

    David A. Albertson & J. Michael Sterchi

Authors
  1. Don V. Jackson Jr.
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  2. Frederick Richards II
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  3. Charles L. Spurr
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  4. Tony R. Long
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  5. Duff A. Rardin
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  6. David A. Albertson
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  7. J. Michael Sterchi
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Jackson, D.V., Richards, F., Spurr, C.L. et al. Hepatic intra-arterial infusion of vincristine. Cancer Chemother. Pharmacol. 13, 120–122 (1984). https://doi.org/10.1007/BF00257127

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  • DOI: https://doi.org/10.1007/BF00257127

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