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High-dose adriamycin (ADM) and cis-platinum (DDP) in advanced soft-tissue sarcomas and invasive thymomas

A pilot study

  • Original Articles
  • Adriamycin, Cis-Platinum
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Summary

Eighteen previously untreated patients with advanced unresectable or metastatic soft-tissue sarcomas (STS) and two patients with locally invasive thymoma were treated with a combination of adriamycin (ADM) 80 mg/m2 on day 1 and cis-platinum (DDP) 120 mg/m2 on day 1. The regimen was repeated at 4-weeks intervals. In STS the overall remission rate was 44%, with 21% complete remissions. The overall survival was 15 months (3–35+), responders surviving a median of 20 months (3–35+) and nonresponders, a median of 9 months (3–20+).

Tumor responses lasted a median of 8 months (3–35+).

Two patients with liposarcoma have now survived disease-free for at least 2 years and are potentially cured.

The two patients with thymoma experienced complete remission lasting 4+ and 20+ months.

Substantial hematologic toxicity was prominent, due to the high-doses used in this combination regimen.

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Authors and Affiliations

  1. Abteilung für Hämatologie/Onkologie, Zentrum Innere Medizin, Universitätskliniken, Theodor-Stern-Kai 7, D-6000, Frankfurt am Main, Federal Republic of Germany

    T. H. Klippstein, P. S. Mitrou, K. J. Kochendörfer & L. Bergmann

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  1. T. H. Klippstein
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  2. P. S. Mitrou
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  3. K. J. Kochendörfer
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  4. L. Bergmann
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Klippstein, T.H., Mitrou, P.S., Kochendörfer, K.J. et al. High-dose adriamycin (ADM) and cis-platinum (DDP) in advanced soft-tissue sarcomas and invasive thymomas. Cancer Chemother. Pharmacol. 13, 78–81 (1984). https://doi.org/10.1007/BF00257118

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  • DOI: https://doi.org/10.1007/BF00257118

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