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2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine

A new potent anticancer drug

  • Original Articles
  • 2,4-Diamino-6-(Bis-2-Chioroethyl)Aminomethyl Pteridine
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Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine has been synthesized and found to be highly potent against L-1210 mouse leukemia lymphoblasts. A single dose of 5 mg/kg injected 24 h after the tumor inoculation increased the life-span of 50% of mice to more than 200%, while the other 505 of animals were cured.

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References

  1. Calabresi P, Parks RE Jr (1980) Chemotherapy of neoplastic disease. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 6th edn. Macmillan, New York, pp 1249–1313

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  2. Khaled MA, Benington E, Morin RD (1984) Patent applications covering this compound and its analogs and homologs have been filed through Research Corporation of USA

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Authors and Affiliations

  1. Department of Nutrition Sciences, The University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    M. Abu Khaled

  2. Neurosciences Program, The University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    M. Abu Khaled, Richard D. Morin & F. Benington

  3. Department of Psychiatry, The University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    Richard D. Morin & F. Benington

  4. Comprehensive Cancer Research Center, The University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    J. Patrick Daugherty

Authors
  1. M. Abu Khaled
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  2. Richard D. Morin
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  3. F. Benington
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  4. J. Patrick Daugherty
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Khaled, M.A., Morin, R.D., Benington, F. et al. 2,4-Diamino-6-(bis-2-chloroethyl)aminomethyl pteridine. Cancer Chemother. Pharmacol. 13, 73–74 (1984). https://doi.org/10.1007/BF00257116

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  • DOI: https://doi.org/10.1007/BF00257116

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