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Does neoplasia in-situ develop due to the interaction of Epstein-Barr virus of herpes simplex virus-2 with Langerhans cells in the epithelium?

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References

  1. Burkitt D., A sarcoma involving the jaws in African children. Brit J Surg 46, 218–223, 1958.

    Google Scholar 

  2. Epstein M.A., Achong B.G. & Barr Y.M., Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 1, 702–703, 1964.

    Google Scholar 

  3. Epstein M.A. & Achong B.G. (eds)., The Epstein-Barr Virus. Springer-Verlag, Berlin-Heidelberg-New York, 1979.

    Google Scholar 

  4. Jondal M., Klein G., Oldstone M.B.A., Bokish V. & Yefenof E., Surface markers on human B and T lymphocytes VIII, Association between complement and Epstein-Barr virus receptors on human lymphoid cells. Scandinavian J Immunol 5, 401–410, 1976.

    Google Scholar 

  5. Lemon S.M., Hutt L.M., Shaw J.E., Li J.L.H. & Pagano J.S., Replication of EBV in epithelial cells during infectious mononucleosis. Nature 268, 268–270, 1977.

    Google Scholar 

  6. Sixbey J.W.W., Vesterinen E.H., Nedrud J.G., Raab-Traub N., Walton L.A. & Pagano J.S., Replication of Epstein-Barr virus in human epithelial cells infected in vitro. Nature, 306, 480–483, 1983.

    Google Scholar 

  7. Glaser R., Lang C.M., Lee K.J., Schuller D.E., Jacobs D. & McQuattie D., Attempts to infect nonmalignant nasopharynegal cells from humans and squirrel monkeys with Epstein-Barr virus. J Natn Cancer Inst 64, 1085–1090, 1980.

    Google Scholar 

  8. Purtilo D.T., Epstein-Barr virus-oncogenesis in immune deficient individuals. in Geraldo G. & Beth E. (eds.) The Role of Viruses in Human Cancer. Volume II. Elsevier Science Publishers BV, Amsterdam, 1984, pp. 119–136.

    Google Scholar 

  9. Galloway D.A. & McDougal J.K., The oncogenic potential of herpes simplex virus: evidence for a “hit-and-run” mechanism. Nature 302, 21–24, 1983.

    Google Scholar 

  10. Jariwalla R.J., Aurelian L. & Ts'o P.O.P., Tumorigenic transformation induced by a specific fragment of DNA from herpes simplex virus type 2. Proc Nat Acad Sci USA 77, 2279–2283, 1980.

    Google Scholar 

  11. Zur Hausen H., The role of viruses in human tumors. Adv Cancer Res 33, 77–107, 1980.

    Google Scholar 

  12. Macnab J.C.M., Herpes simplex virus and human cytomegalovirus: their role in morphological transformation and genital cancers. J Gen Virol 68, 2525–2550, 1987.

    Google Scholar 

  13. Oguchi M., Komura J., Tagami H. & Ofuji S., Ultrastructural studies of spontaneous regressing plane warts. Langerhans cells show marked activation. Arch Dermatol Res 271, 55–61, 1981.

    Google Scholar 

  14. Shamoto M., Langerhans cells increase in dermal lesions of adult T cell leukemia in Japan. J Clin Pathol 36: 307–311, 1983.

    Google Scholar 

  15. Gatter K.C., Morris H.B., Roach B., Mortimer P., Fleming K.A. & Mason D.Y., Langerhans cells and T cells in human skin tumors: an immunohistological study. Histopathology 8, 229–244, 1984.

    Google Scholar 

  16. Tschachler E., Groh V., Popovic M., Mann D.L., Konrad K., Safari B., Eran L., diMarzo-Veronese F., Wolff K. & Stingl G., Epidermal Langerhans cells—a target of HTLVIII/LAV infection. J Invest Dermatol 88, 233–237, 1987.

    Google Scholar 

  17. Koulu L. & Jansen T., Langerhans cells in xeroderma pigmentosum. J Invest Dermatol 80, 374, 1983.

    Google Scholar 

  18. Theirs B.H., Maize J.C., Spicer S.S. & Cantor A.B., The effect of aging and chronic sun exposure on human Langerhans cell population. J Invest Dermatol 82, 223–226, 1984.

    Google Scholar 

  19. Langerhans P., Über die Nerven der menschlichen Haut. Virchows Arch Pathol Anat Physiol 44, 325–337, 1868.

    Google Scholar 

  20. Jimbow K., Sato S. & Kukita A., Cells containing Langerhans granules in human lymph nodes of dermathopathic lymphadenitis. J Invest Dermatol 53, 295–299, 1969.

    Google Scholar 

  21. Rausch E., Kaiserling E. & Goos M., Langerhans cells and human dermatopathic lymphadenitis. Virchows Arch (Cell Pathol) 25, 3237–343, 1977.

    Google Scholar 

  22. Shamoto M., Kaplan C. & Katoh A.K., Langerhans cell granules in human hyperplastic lymph nodes. Arch Pathol 92, 46–52, 1971.

    Google Scholar 

  23. Hoshino T., Kukita A. & Sato S., Cells containing Birbeck granules (Langerhans cell granules) in human thymus. J Electron Microsc 19, 271–276, 1970.

    Google Scholar 

  24. Hashimoto K. & Tarnowski W.M., Some new aspects of Langerhans cells. Arch Dermatol 97, 450–464, 1968.

    Google Scholar 

  25. Yassin T.M. & Toner P.G., Langerhans cells in human oesophagus. J Anat 122, 435–445, 1976.

    Google Scholar 

  26. Geboes K., De Wolf-Peeters C., Rutgeerts P., Janssens J., Vantrappen G. & Desmet V., Lymphocytes and Langerhans cells in human oesophageal epithelium. Virchows Arch (A) 401, 45–55, 1983.

    Google Scholar 

  27. Löning T., Caselitz J., Seifert G., Weber K. & Osborn M., Identification of Langerhans cells: simultaneous use of sera to intermediate filament, T6 and HLA-DR antigens on oral mucosa of human epidermis and thier tumors. Virchows Arch (A) 398, 119–128, 1982.

    Google Scholar 

  28. Daniels T.E., Human mucosal Langerhans cells: postmortem identification of regional variations in oral mucosa. J Invest Dermatol 82, 21–24, 1984.

    Google Scholar 

  29. Tagawa Y., Takeuchi T., Saga T.J. & Matsuda H., The Langerhans cells in the cornea and conjuctiva its distribution and Ia antigens. Nippon Ganka Gakkai Zasshi 86, 825–832, 1982.

    Google Scholar 

  30. Hazlett L.D., Change with age in limbal conjunctival epithelial Langerhans cells. Curr Eye Res 2, 423–425, 1982/3.

    Google Scholar 

  31. Stingl G., Wolff-Schreiner E.C., Pichler W.J., Gschnait F., Knapp W., & Wolff K., Epidermal Langerhans cells bear Fc and C3 receptors. Nature 268, 245–246, 1977.

    Google Scholar 

  32. Klareskog L., Tjernlund U.M., Forsum U. & Peterson P.A., Epidermal Langerhans cells express Ia antigens. Nature 268, 248–250, 1977.

    Google Scholar 

  33. Silverberg-Sinakin I., Thorbecke G.J., Baer R.L., Rosenthal S.A., & Berezowsky V., Antigen-bearing Langerhans cells in skin dermal lymphatics and lymph nodes. Cell Immunol 25, 137–151, 1976.

    Google Scholar 

  34. Murphy G.F., Bhan A.K., Sato S., Mihun M.C. Jr & Harris T.J., A new immunological marker for human Langerhans cells. N Engl J Med 304, 791–792, 1981.

    Google Scholar 

  35. Sander D.N., Dinarello C.A. & Morhenn V.B., Langerhans cell production of interleukin-1. J Invest Dermatol 82, 605–607, 1984.

    Google Scholar 

  36. Stingl G., Katz S.I., Green I. & Shevah E.M., The functional role of Langerhans cells. J Invest Dermatol 74, 315–318, 1980.

    Google Scholar 

  37. Katz S.I., Tamaki K. & Sachs D.H., Epidermal Langerhans cells are derived from cells originating in the bone marrow. Nature 282, 324–327, 1979.

    Google Scholar 

  38. Balfour B.M., Drexhage H.A., Kamperdijk E.W. & Hoefsmit E.C., Antigen-presenting cells, including Langerhans cells, veiled cells and interdigitating cells. Ciba Foundation Symp 84, 281–301, 1980.

    Google Scholar 

  39. Tjernlund U. & Juhlin L. Effect of uv irridation on immunological and histochemical markers of Langerhans cells in normal appearing skin of psoriatic patients. Arch Dermatol Res 272, 171–176, 1982.

    Google Scholar 

  40. Perry L.L. & Green M.I., Antigen presentation by epidermal Langerhans cells: loss of function following ultraviolet (uv) irridation in vivo. Clin Immunol Immunopathol 24, 204–219, 1982.

    Google Scholar 

  41. Gurish M.F., Lynch D.H., Yowell R. & Daynes R.A., Abrogation of epidermal antigen-presenting cell function by ultraviolet radiation administered in-vivo. Transplantation 36, 304–309, 1983.

    Google Scholar 

  42. Schwartz J.L., Weichselbaum R., Frim S.R., The effect of aging on the density and distribution of oral mucosal Langerhans cells. Exp Gerontol 18, 65–71, 1983.

    Google Scholar 

  43. Morris H.H., Gatter K.C., Stein H. & Mason D.Y., Langerhans cells in human cervical epithelium: an immunohistological study. Br J Obstet Gynaecol 90, 400–411, 1983.

    Google Scholar 

  44. Bjercke S., Scott H., Braathen L.R. & Thorsby E., HLA-DR expressing Langerhans-like cells in vaginal and cervical epithelium. Acta Obstet Gynecol Scand 62, 585–589, 1983.

    Google Scholar 

  45. Kanerva L., Lauharanta J. & Niemi K.M., Electron microscopic observations of mitotic Langerhans cells as possible sign of retinoid induced stimulation. J Cutan Pathol 11, 138–143, 1983.

    Google Scholar 

  46. Kobayashi M., Influence of aromatic retinoid on epidermal Langerhans cells. Nippon Hifuka Gakkai Zasshi 93, 763–771, 1983.

    Google Scholar 

  47. Koulu L. & Jansen T., Epidermal Langerhans cell number and morphology during oral retinoid treatment. Arch. Dermatol. Res. 272, 135–137, 1982.

    Google Scholar 

  48. Fernandez-Bussy R.A., Schmidt D. & Mauduit G., Thivolet J.. Effects of armatic retinoid (RO 109359) on Langerhans cells in lichen planus. Arch Dermatol Res 275, 105–108, 1983.

    Google Scholar 

  49. Streilein J., Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol 80, (Suppl.): 12–16, 1983.

    Google Scholar 

  50. Warner T.F. & Reza Hafez G., Langerhans cell tumor of the eyelid. J Cutan Pathol 9, 417–422, 1982.

    Google Scholar 

  51. Uchiyama T., Yodoi J., Sagawa K., Takatsuki K. & Uchino H., Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50, 481–492, 1977.

    Google Scholar 

  52. Shamoto M., Murakami S. & Zenke T. Adult T-cell leukemia in Japan: an ultrastructural study. Cancer 47, 1804–1811, 1981.

    Google Scholar 

  53. Van der Loo E.M., Van Muijen G.N.P., Van Vloten W.A., Beens W., Scheffer E. & Meijer C.J.L.M., C-type virus-like particles specifically localized in Langerhans cells and related cells of skin and lymph nodes of patients with mycosis fungoides and Sezary syndrome. A morphological and biochemical study. Virchows Arch (Cell Pathol) 31, 193–203, 1979.

    Google Scholar 

  54. Chu A., Berger C.L., Jung P. & Edelson R.L., In situ identification of Langerhans cells in the dermal infiltrate of cutaneous T cell lymphoma. J Am Acad Dermatol 6, 350–354, 1982.

    Google Scholar 

  55. Ryan E.A., Sanderson K.V., Bartak P. & Samman P.D., Can mycosis fungoides begin in the epidermis: a hypothesis. Br J Dermatol 88, 419–429, 1973.

    Google Scholar 

  56. Rowden G. & Lewis M.G., Langerhans cells: involvement in the pathogenesis of mycosis fungoides. Br J Dermatol 95, 665–672, 1976.

    Google Scholar 

  57. Rowden G., Target role of Langerhans cells in mycosis fungoides: transmission and immunoelectron microscopic studies. J Cutan Pathol 6, 364–382, 1979.

    Google Scholar 

  58. Schmitt D. & Thivolet J., Lymphocyte epidermis interactions in malignant epidermotropic lymphomas. I. Ultrastructural aspects. Acta Derm Venereol (Stockh) 60, 1–11, 1980.

    Google Scholar 

  59. Saito T., Honma T. & Saigo K., Epidermal Langerhans cells after the prick test for Behcet's disease. Dermatologica 161, 152–156, 1980.

    Google Scholar 

  60. Kohn S., Haim S., Gilhar A., Friedman-Birnbaum R. & Nir I., Epidermal Langerhans cells in Behcet's disease. J Clin Pathol 37, 616–619, 1984.

    Google Scholar 

  61. Epstein A.L., Levy R., Kim H., Henle W., Henle G. & Kaplan H.S., Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines. Cancer 42, 2379–2391, 1978.

    Google Scholar 

  62. Belsito D.V., Sanchez M.R., Baer R.L., Valentine F. & Thorbecke G.J., Reduced Langerhans cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome. N Engl J Med 310, 1279–1282, 1984.

    Google Scholar 

  63. Shapiro I.M. & Volsky D.J., Infection of normal human epithelial cells by Epstein-Barr virus. Science 219, 1225–1228, 1983.

    Google Scholar 

  64. Stoerker J., Parris D., Yajima Y. & Glaser R., Pleiotropic expression of Epstein-Barr virus DNA in human epithelial cells. Proc Natl Acad Sci USA 78, 5852–5855, 1981.

    Google Scholar 

  65. Miller G., Grogan E., Heston L., Robinson J. & Smith D., Epstein-Barr viral DNA: infectivity for human placental cells. Science 212, 452–455, 1981.

    Google Scholar 

  66. Yura Y., Iga H., Terashima K., Yoshida H., Yanagawa T., Hayashi Y. & Sato M., The role of epithelial cell differentiation in the expression of herpes simplex type 1 in normal human oral mucosa in culture. Arch Virol. 92, 41–53, 1987.

    Google Scholar 

  67. Klein G., The relationship of the virus to nasopharyngeal carcinoma, in Epstein M.A. & Achong B.G. (eds) The Epstein-Barr Virus. Springer-Verlag, Berlin-Heidelberg-New York, 1979, pp. 339–350.

    Google Scholar 

  68. de-The G., Demographic studies implicating the virus in the causation of Burkitt's lymphoma; prospects for nasopharyngeal carcinoma, in Epstein M.A. & Achong B.G. (eds) The Epstein-Barr Virus. Springer-Verlag, Berlin-Heidelberg-New York, 1979, pp. 417–437.

    Google Scholar 

  69. Jenkin R.D.T., Anderson J.R., Jereb B., Thompson J.C., Pyesmany A., Wara W.M. & Hammond D., Nasopharyngeal carcinoma—a retrospective review of patients less than thirty years of age: a report from children's cancer study group. Cancer 47, 360–366, 1981.

    Google Scholar 

  70. Marks J.E., Bedwineck J.M., Lee F., Purdy J.A. & Perz C.A., Dose-response analysis for carcinoma. Cancer 50, 10042–1050, 1982.

    Google Scholar 

  71. Cooper J.S., Rowe J.D. & Newell J., Regional stage IV carcinoma of the nasopharynx treated by aggressive radiotherapy. Int J Radiat Oncol Biol Phys 9, 1737–1745, 1983.

    Google Scholar 

  72. Brichacek B., Hirsch I., Suchankova A., Vilikusova E., Sibl O., Zavadova H. & Vonka V. Association of EBV with some carcinomas orginating in Waldeyer ring outside nasopharynx, in Giraldo G. & Beth E. (eds.) The Role of Viruses in Human Cancer, Vol II, Elsevier Science Publishers BV, Amsterdam, 1984, pp. 137–151.

    Google Scholar 

  73. Naib Z.M., Nahmias A.J. & Josey W.E., Cytology and histopathology of cervical herpes simplex infection. Cancer 19, 1026–1031, 1966.

    Google Scholar 

  74. Rawls W.E., Tompkins W.A.F. & Melnick J.L., The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidem 89, 547–554, 1969.

    Google Scholar 

  75. Nahmias A.F., Josey W.E., Naib Z.M., Luce C.F. & Guest B., Antibodies to herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. Am J Epidem 91, 547–552, 1970.

    Google Scholar 

  76. Adam E., Kaufman R.H., Melnick J.L., Levy A.H. & Rawls W.E. Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. 3. Houston, Texas. Am J Epidem 96, 427–442, 1972.

    Google Scholar 

  77. McDougnall J.K., Galloway D.A. & Fenoglio C.M., Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change. Int J Cancer 25, 1–8, 1980.

    Google Scholar 

  78. McDougall J.K., Crum C.P., Fenoglio C.M., Goldstein L.C. & Galloway D.A. Herpesvirus-specific RNA and protein in carcinoma of the uterine cervix. Proc Natl Acad Sci USA 79, 3853–3857, 1982.

    Google Scholar 

  79. Eglin R.P., Sharp F., Maclean A.B., Macnab J.C.M., Clemonts J.B. & Wilkie N.M., Detection of RNA complementary to herpes simplex virus DNA in human cervical squamous cell neoplasms. Cancer Res 41, 3597–3603, 1981.

    Google Scholar 

  80. Chardonnet Y., Beauve P., Viac J. & Schmitt D., T-cell subsets and Langerhans cells in wart lesions. Immunol Lett 6, 191–196, 1983.

    Google Scholar 

  81. Guillet G., Braun L., Shah K. & Ferenczy A., Papillomavirus in cervical condylomas with and without associated cervical intraepithelial neoplasma. J Invest Dermatol 81, 513–516, 1983.

    Google Scholar 

  82. Green M., Brackmann K.H., Sanders P.R., Loewenstein P.M., Freel J.H., Eisinger M., & Switlyk S.A. Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: Presence of related viral DNA genomes in human urogenital tumors. Proc Natl Acad Sci USA 79, 4437–4441, 1982.

    Google Scholar 

  83. Zur Hausen H., Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events? Lancet ii, 1370–1372, 1982.

    Google Scholar 

  84. Durst M., Gissman L., Ikenberg H. & zur Hausen H., A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 80, 3812–3815, 1983.

    Google Scholar 

  85. Gross L., Warts and papillomas in man, in Oncogenic Viruses, Vol. 1. Pergamon Press, Oxford-New York, 1983, pp 72–76.

    Google Scholar 

  86. Hosking A.R., The influence of vitamin A on epithalial Langerhans cells of murine buccal and vaginal mucosae. Aust Dent J 26, 175–0107, 1981.

    Google Scholar 

  87. Braathen L.R., Berle E., Mobech-Hanssen U. & Thorsby E., Studies on human epidermal Langerhans cells: II. Activation of human T lymphocytes to herpes simplex virus. Acta Derm Venereol (Stockholm) 60, 381–387, 1980.

    Google Scholar 

  88. Aurelian L., Viruses and antigens of herpes virus type 2 in cervical carcinoma. Cancer Res 33, 1539–1547, 1973.

    Google Scholar 

  89. Aurelian L., Manak M.M. & Ts'o P.O.P., HSV-2 and cervical cancer: the transformation lesson, in Giraldo G. & Beth E. (eds.), The Role of Viruses in Human Cancer Vol II, Elsevier Science Publishers BV, Amsterdam, 1984, pp. 73–86.

    Google Scholar 

  90. Jarrett W.F.H., Bracken fern and papilloma virus in bovine alimentary cancer. Brit Med Bull 36, 79–81, 1980.

    Google Scholar 

  91. Sprecher E. & Becker Y., Skin Langerhans cells play an essential role in the defense aginst HSV-1 infections. Arch. Virol. 51, 341–349, 1986.

    Google Scholar 

  92. Sprecher E. & Becker Y., HSV-1 pathogenicity in footpad and ear skin of mice depends on Langerhans cell density, mouse genetics and virus strain. J. Virol. 61, 2515–2522, 1987.

    Google Scholar 

  93. Becker Y., Does radiation-induced abrogation of skin Langerhans cell functions lead to enhanced incidence of skin tumors in patients with genetic disorders of DNA repair? Cancer Invest. 5, 505–513, 1987.

    Google Scholar 

  94. Daniels T.E., Greenspan D., Greenspan J.S., Lennette E., Schiodt M., Petersen V. & DeSouza Y. J Invest Dermatol 89, 178–182, 1987.

    Google Scholar 

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Becker, Y. Does neoplasia in-situ develop due to the interaction of Epstein-Barr virus of herpes simplex virus-2 with Langerhans cells in the epithelium?. Virus Genes 1, 385–397 (1988). https://doi.org/10.1007/BF00257101

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