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The acute effects of various cytotoxic compounds injected into the prostate glands of dogs

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Summary

The acute effects of direct injections with various cytotoxic compounds into the prostates of adult dogs were studied microscopically. The effects remained localised to the site of injection, with no diffusion of the agents into other areas of the prostate. No systemic effects were observed despite the high concentrations used. The main histological changes consisted of focal aseptic necrosis at the injection site surrounded by atrophy of the acinar epithelium.

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Authors and Affiliations

  1. Department of Urology, Ichilov Hospital, University of Tel Aviv, Israel

    M. Firstater, A. Meshorer, A. Tadmor & L. Itzicovitch

  2. Experimental Animal Center, Weizmann Institute of Science, Rehovoth, Israel

    M. Firstater, A. Meshorer, A. Tadmor & L. Itzicovitch

  3. Kimron Veterinary Institute, Beit Dagan, Israel

    M. Firstater, A. Meshorer, A. Tadmor & L. Itzicovitch

  4. 6 Uri St., Tel-Aviv, Israel

    M. Firstater

Authors
  1. M. Firstater
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  2. A. Meshorer
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  3. A. Tadmor
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  4. L. Itzicovitch
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Firstater, M., Meshorer, A., Tadmor, A. et al. The acute effects of various cytotoxic compounds injected into the prostate glands of dogs. Urol. Res. 6, 13–17 (1978). https://doi.org/10.1007/BF00257077

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  • DOI: https://doi.org/10.1007/BF00257077

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