Summary
Reactivity of regional lymph node cells was determined in 87 patients with urological cancer by measuring the S-phases of the cell cycle using flow cytophotometry. Compared with a control group of 28 individuals with and without infectious disease regional to the extirpated lymph nodes, analysis of 250 lymph nodes in tumour patients exhibited either normal, reduced, or elevated S-phase. No relation could be established between the reduced or elevated pattern of reactivity of regional lymph node cells and any known tumour parameter, such as organ manifestation, histology, stage, and grade. Whether the determined S-phases correlate with the prognosis remains to be determined.
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Agashe SS, Gangal SG, Nair PNM, Rao RS (1976) Reactivity of regional lymph node cells from osteosarcoma patients on target osteosarcoma cells. Indian J Med Res 64:1657
Barna BP, Deodhar SD (1979) Immunological activity of regional lymph nodes in tumor-bearing mice. Cancer Res 39:2711
Catalona WJ, Ratliff TL, McCool RE (1979) Concanavalin A-inducible suppresor cells in regional lymph nodes of cancer patients. Cancer Res 39:4372
Ciocca DR (1980) Immunomorphologic lymph node changes in rats bearing experimental breast tumors. Am J Pathol 99:193
Collste LG, Darzynkiewicz Z, Traganos F, Sharpless TK, Whitmore WF Jr, Melamed MR (1979) Regional lymph node reactivity in explanted bladder cancer of mice as measured by flow cytometry. Cancer Res 39:2120
Dreesen C, Kitschke HJ, Krebs D, Stegner HE, Arning F, Böcker W (1979) Untersuchungen zur zellulären Immunität der regionären Lymphknoten bei Mammakarzinom-Patientinnen. Arch Gynecol 228:607
Eremin O, Ashby J, Franks D (1977) Killer (K) activity in human normal lymph node, regional tumour lymph node and inflammatory lamph node. Int Arch Allergy Appl Immunol 54:210
Fisher B, Saffer EA, Fisher ER (1974) Studies concerning the regional lymph node in cancer. VII. Thymidine uptake by cells from nodes of breast cancer patients relative to axillary location and histopathologic discriminants. Cancer 33:271
Fisher B, Saffer E, Fisher ER (1974) Studies concerning the regional lymph node in cancer. IV. Tumor inhibition by regional lymph node cells. Cancer 33:631
Gillette RW, Boone CW (1975) Changes in the mittogen response of lymphoid cells with progressive tumor growth. Cancer Res 35:3774
Goerttler K, Stöhr M (1979) Quantitative cytology of the positive region in flow sorted vaginal smears. J Histochem Cytochem 27:567
Herr HW, Bean MA, Whitmore WF (1976) Prognostic significance of regional lymph node histology in cancer of the bladder. J Urol 115:264
Herr HW (1977) Immunologic reactivity of lymph nodes regional to prostatic cancer: Preliminary observations. J Surg Oncol 9:509
Herr HW (1977) Suppressor cell activity in lymph nodes regional to bladder carcinoma. Surg Forum 28:546
Jones JA, Robinson G, Rees RC, Baldwin RW (1978) Immune response of the draining and distal lymph nodes during the progressive growth of a chemically-induced transplantable rat hepatoma. Int J Cancer 21:171
Kiricuta I, Todorutiu C, Mulea R, Risca R (1978) Axillary lymph node and breast carcinoma interrelations in organ culture. Cancer 42:2710
Kojima O, Fujita Y, Oh A, Sakita M, Nishioka B, Majima S (1980) Immunomorphologic study of regional lymph nodes in cancer: response of regional lymph node cells from gastric and colorectal cancer to PHA stimulation. Jpn J Surg 10:212
Schwabe HW, Adolphs H-D (1982) Improved application of impulse cytophotometry for the diagnosis of urinary bladder carcinoma. Urol Res 10:61
Stöhr M, Gebhardt U, Goerttler K (1976) Computer assistance in multiparameter flow microphotometry of mammilian cells. Biotechnol Bioeng 18:1057
Syrjänen KJ (1979) Bronchial carcinoma and its regional lymph nodes in relation to immunological functions. Z Immunforsch 155:212
Tribukait B, Gustafson H (1980) Impulszytophotometrische DNS-Untersuchungen bei Blasenkarinomen. Onkologie 6:278
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Adolphs, H.D., Schwabe, H.W. Lymph node proliferation in patients with urological tumours. Urol. Res. 11, 53–57 (1983). https://doi.org/10.1007/BF00256947
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DOI: https://doi.org/10.1007/BF00256947