Abstract
Radiolabelled enema solution was administered to eight healthy subjects, both in fasted and fed states. Enema spreading was monitored over a 4-h period using gamma scintigraphy and colonic motility was recorded simultaneously using a pressure sensitive radiotelemetry capsule. The rate and extent of enema dispersion were unaffected by eating. Spreading could be correlated with colonic motility and was inhibited by aboral propulsion of the colonic contents.
Similar content being viewed by others
References
Farthing MJG, Rutland MD, Clark ML (1979) Retrograde spread of hydrocortisone containing foam given intrarectally in ulcerative colitis. Br Med J 2:822–824
Hay DJ (1982) Spreading characteristics of proprietary rectal steroid preparations. In: Wilson CG, Hardy JG, Frier M, Davis SS (eds) Radionuclide imaging in drug research. Croom Helm, London Canberra, pp 171–180
Holdstock DJ, Misiewicz JJ (1970) Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer. Gut 11:100–110
Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EN (1970) Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut 11:91–99
McIntyre PB, Macrae FA, Berghouse L, English J, Lennard-Jones JE (1983) Poorly absorbed prednisolone retention enema gives good therapeutic results in distal colitis. Gut 24:A998-A999
Misiewicz JJ, Waller SL, Eisner M (1966) Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro. Gut 7:208–216
Snape WJ, Matarazzo SA, Cohen S (1978) Effect of eating and gastrointestinal hormones on colonic myoelectrical and motor activity. Gastroenterology 75:373–378
Swarbrick ET, Loose H, Lennard-Jones JE (1974) Enema volume as an important factor in successful topical corticosteroid treatment of colitis. Proc R Soc Med 67:753–754
Wood E, Wilson CG, Hardy JG (1985) The spreading of foam and solution enemas. Int J Pharmaceutics 25:191–197