Abstract
The measurement of body/venous haematocrit ratio has been assessed in 329 cases, in order to study the degree of error if the total blood volume were calculated from the red cell or plasma volume, using a pre-established correction factor. Three facts are clear from this study: (1) the ratio (correction factor f) is slightly lower than in the previous published data; (2) in polycythaemic and normal subjects, a low dispersion of the results around the mean value makes the potential error very low in all the cases; (3) in patients with an enlarged spleen, with anaemia and with dysproteinaemia, the large variation from case to case of the body/venous haematocrit ratio could cause large errors in determining total blood volume when using such a simplified method.
This is a preview of subscription content, log in via an institution to check access.
References
Bernaille C, Vallee G (1964) Intérêt clinique des techniques de double marquage simultané plasmatique et globulaire. Pathol Biol [Paris] 12:426–433
Bowdler AJ (1972) Plasma volume and splenomegaly in polycythaemia vera. Br J Haematol 22:331–339
Chaplin H, Mollison PL (1952) Correction for plasma trapped in the red cell column of the hematocrit. Blood 7:1227
Chaplin H, Mollisson PL, Vetter H (1953) The body/venous hematocrit ratio: its constancy over a wide hematocrit range. J Clin Invest 32:1309–1321
Cocking JB, Wilson E (1972) The whole body/venous haematocrit ratio in chronic non-specific obstructive lung disease. Scand J Haematol 9:433–436
Donaldson GWK, MacArthur M, MacPherson AIS, Richmond (1970) Blood volume changes in splenomegaly. Br J Haematol 18:45–55
Dosik M, Pasad B (1978) Coulter S hematocrit and microhematocrit in polycythemic patients. Am J Hematol 5:51–54
England JM, Down MC (1975) Determination of the packed cell volume using 131-I human serum albumin. Br J Haematol 30:365–370
Fudenberg H, Bladini M, Mahoney JP, Dameshek W (1961) The body hematocrit/venous hematocrit ratio and the “splenic reservoir”. Blood 17:71–82
Garby L, Vuille JC (1961) The amount of trapped plasma in a high speed microcapillary hematocrit centrifuge. Scand J Clin Lab Invest 13:642–648
Hope A, Verel D (1955) Observation on the distribution of red cells and plasma in disease: the low body haematocrit/venous haematocrit ratio. Clin Sci 14:501
International Committee for Standardization in Haematology (ICSH) (1973) Standard techniques for the measurement of red cell and plasma volumes. Br J Haematol 25:801
Najean Y, Cacchione R (1977) Blood volume in health and disease. Semin Haematol 6:543–566
Penn D, Williams PR, Dutcher TF, Adair RM (1979) Comparison of hematocrit determinations by micro hematocrit and electronic particle counters. Am J Clin Pathol 72:71–74
Rothschild MA, Bauman A, Yalow RS, Berson SA (1954) Effect of splenomegaly on blood volume. J Appl Physiol 6:701
Tuckman J, Blumberg A (1976) Serial measurements of total blood volume in patients on maintenance dialysis. Klin Wochenschr 54:735–738
Valeri CR, Cooper AG, Pivacek LE (1973) Limitations of measuring blood volume with iodinated I-125 serum albumin. Arch Intern Med 132:534–538
Wennesland R, Brown E, Hopper J, Hodges JL, Guttentag DE, Scott KG, Tucker IN, Bradley B (1959) Red cell, plasma and blood volume in healthy men measured by radio-chromium cell tagging and hematocrit. J Clin Invest 38:1065–1077
Wright RR, Tono M, Pollycove M (1975) Blood volume. Semin Nucl Med 5:63–78
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Najean, Y., Deschrywer, F. The body venous haematocrit ratio and its use for calculating total blood volume from fractional volumes. Eur J Nucl Med 9, 558–560 (1984). https://doi.org/10.1007/BF00256856
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256856