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Minimization of inflammation in the treatment of bladder tumors by intravesical instillation of Adriamycin

  • Bladder Cancer, Adriamycin
  • Published:
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Summary

The purpose of this trial was to minimize local infalammation caused by intravesical instillation of antitumor agents, especially Adriamycin, in the treatment of bladder tumor. Tranexamic acid was chosen as the solvent vehicle for Adriamycin and IV bolus injection of an antiallergic drug, Stronger neo-minophagen C, was given at the time of each instillation.

Of 81 cases scheduled for Adriamycin instillation therapy, nine cases (11.1%) dropped out due to severe bladder inflammation, while 17 other cases (21%) experienced local side-effects which were tolerated. Of 62 evaluable cases in whom more than eight instillations were performed, complete regression was observed in six cases (9.7%) and partial regression in 20 cases (32.3%).

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Authors and Affiliations

  1. Department of Urology, School of Medicine, Kagoshima University, 1208-1, Usuki-cho, 890, Kagoshima, Japan

    Yoshitada Ohi, Kenichiro Okamoto, Takashi Kawabata, Akinori Hanafusa, Chan Ying Fai, Toshiaki Kakinoki & Motoshi Kawahara

  2. Division of Urology, Kagoshima City Hospital, Kagoshima, Japan

    Setsuo Asechi & Nichiro Sakamoto

  3. Division of Urology, Saga Prefectural Hospital, Saga, Japan

    Shinichi Nagata & Shizuo Yagi

Authors
  1. Yoshitada Ohi
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  2. Kenichiro Okamoto
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  3. Takashi Kawabata
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  4. Akinori Hanafusa
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  5. Chan Ying Fai
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  6. Toshiaki Kakinoki
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  7. Motoshi Kawahara
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  8. Setsuo Asechi
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  9. Nichiro Sakamoto
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  10. Shinichi Nagata
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  11. Shizuo Yagi
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Ohi, Y., Okamoto, K., Kawabata, T. et al. Minimization of inflammation in the treatment of bladder tumors by intravesical instillation of Adriamycin. Cancer Chemother. Pharmacol. 11 (Suppl 1), S83–S88 (1983). https://doi.org/10.1007/BF00256726

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  • DOI: https://doi.org/10.1007/BF00256726

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