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Cooperative studies of systemic chemotherapy

A review of the work of the EORTC Urological Group and of the Yorkshire Urological Cancer Research Group (YUCRG)

  • Chemotherapy, Bladder Cancer
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References

  1. Bertino JR (1982) Adjuvant chemotherapy and cancer cure. Int J Radiat Oncol Biol Phys 8: 113

    Google Scholar 

  2. Bloom HJG (1981) Pre-operative intermediate-dose radiotherapy and cystectomy for deeply invasive carcinoma of the bladder: Rationale and results. In: Oliver RTD, Hendry WF, Bloom HJG (eds) Bladder cancer — Principles of combination therapy. Butterworths, London, pp 151–174

    Google Scholar 

  3. Bloom HJG, Hendry WF, Wallace DM, Skeet RG (1982) Treatment of T3 bladder cancer: Controlled trial of pre-operative radiotherapy and radical cystectomy versus radical radiotherapy. Second report and review (for the Clinical Trials Group, Institute of Urology). Br J Urol 54: 136–151

    Google Scholar 

  4. Campbell M, Baker LH, Opipari M, Al-Sarraf M (1981) Phase II trial with cisplatin, doxorubicin, and cyclophosphamide (CAP) in the treatment of urothelial transitional cell carcinoma. Cancer Treat Rep 65: 897–899

    Google Scholar 

  5. Carter SK, Wasserman TH (1975) The chemotherapy of urologic cancer. Cancer 36: 729–747

    Google Scholar 

  6. Cummings KB, Shipley WU, Einstein AB, Cutler SJ (1979) Current concepts in the management of patients with deeply invasive bladder cancer. Semin Oncol 6: 220–228

    Google Scholar 

  7. De Jager R, Cappelaere P, Earl H, Rubens R, Stuart Harris R, Smith I, Renard J, van Glabbeke M, Mathé G (1981) Phase II clinical trial of mitoxantrone in solid tumors. NCI-EORTC Symposium on New Drugs, Abstract 39

  8. Edsmyr F (1981) Radiotherapy in the management of bladder cancer. In: Oliver RTD, Hendry WF, Bloom HJG (eds) Bladder cancer — Principles of combination therapy. Butterworths, London, pp 139–149

    Google Scholar 

  9. EORTC Urological Group (1977) The treatment of advanced carcinoma of the bladder with a combination of Adriamycin and 5-fluorouracil. Eur J Urol 3: 276–278

    Google Scholar 

  10. Fox M (1965) The effect of cyclophosphamide on some urinary tract tumours. Br J Urol 37: 399–405

    Google Scholar 

  11. Herr HW (1980) cis-Diamminedichloride platinum II in the treatment of advanced bladder cancer. J Urol 123: 853–855

    Google Scholar 

  12. Hope-Stone HF, Blandy JP, Oliver RTD, England H (1981) Radical radiotherapy and salvage cystectomy in the treatment of invasive carcinoma of the bladder. In: Oliver RTD, Hendry WF, Bloom HJG (eds) Bladder cancer — Principles of combination therapy. Butterworths, London, pp 127–138

    Google Scholar 

  13. Johnson RK, Zee-Cheng RKY, Lee WW, Acton FM, Henry DW, Cheng CC (1979) Experimental antitumor activity of aminoanthraquinones. Cancer Treat Rep 63: 425–539

    Google Scholar 

  14. Kedia KR, Gibbons C, Persky L (1981) The management of advanced bladder carcinoma. J Urol 125: 655–658

    Google Scholar 

  15. Levi JA, Aroney RS, Dalley DN (1980) Combination chemotherapy with cyclophosphamide doxorubicin, and bleomycin for metastatic transitional cell carcinoma of the urinary tract. Cancer Treat Rep 64: 1011–1013

    Google Scholar 

  16. Martino S, Samal B, Al-Saraff M (1980) Phase II study of 5-fluorouracil and Adriamycin in transitional cell carcinoma of the urinary tract. Cancer Treat Rep 64: 161–163

    Google Scholar 

  17. Merrin C, Cartagena R, Wajsman Z, Baumgartner G, Murphy GP (1975) Chemotherapy of bladder cancer with cyclophosphamide and Adriamycin. J Urol 114: 884–887

    Google Scholar 

  18. Miller LS (1977) Bladder cancer: Superiority of preoperative irradiation therapy and cystectomy in clinical stages B2 and C. Cancer 39: 973–980

    Google Scholar 

  19. Mulder JH, Fossa SD, De Pauw M, Van Oosterom AT (1982) Cyclophosphamide, Adriamycin and cisplatin combination chemotherapy in advanced bladder carcinoma: An EORTC phase II study. Eur J Cancer Clin Oncol 18: 111–112

    Google Scholar 

  20. Murphy GP (1975) The current status of bladder cancer. In: Nyhus LM (ed) Surgery annual, vol 7. Appleton-Century Crofts, New York, pp 175–218

    Google Scholar 

  21. Natale RB, Yagoda A, Watson RC, Whitmore WF, Blumenreich M, Braun DW Jr (1981) Methotrexate — an active drug in bladder cancer. Cancer 47: 1246–1250

    Google Scholar 

  22. O'Bryan RM, Baker LH, Gottlieb JE, Riukin SE, Balcerzak SP, Grumet GN, Salmon SE, Moon TE, Hoogstraten B (1977) Dose response evaluation of Adriamycin in human neoplasm. Cancer 39: 1940–1948

    Google Scholar 

  23. Paulson DF, Perez CA, Anderson T (1981) Genito-urinary malignancies. In: De Vita VT Jr, Hellman S, Rosenberg S (eds) Cancer — Principles and practice of oncology. Lippincott, Philadelphia Toronto, pp 745–753

    Google Scholar 

  24. Peters PC, O'Neill MR (1980) cis-Diamminedichloroplatinum as a therapeutic agent in metastatic transitional cell carcinoma. J Urol 123: 375–377

    Google Scholar 

  25. Prout GR Jr, Griffin PP, Shipley WU (1979) Bladder carcinoma as a systemic disease. Cancer 43: 2532–2539

    Google Scholar 

  26. Rodriguez LH, Johnson DE, Holoye PY, Samuels ML (1977) Combination of VM-26 and Adriamycin for metastatic transitional cell carcinoma. Cancer Treat Rep 61: 87–88

    Google Scholar 

  27. Skinner DG (1980) Current perspectives in the management of high-grade invasive bladder cancer. Cancer 45: 1866–1874

    Google Scholar 

  28. Smith JA, Whitmore WF (1981) Regional lymph node metastasis from bladder cancer. J Urol 126: 591–593

    Google Scholar 

  29. Smith PH (1983) Invasive bladder cancer — A lethal enigma. In: Smith PH, Prout GR (eds) Bladder cancer. Butterworths, London (in press)

    CAS  PubMed  Google Scholar 

  30. Soloway MS, Ikard M, Ford K (1981) cis-Diamminedichloroplatinum (II) in locally advanced and metastatic urothelial cancer. Cancer 47: 467–480

    Google Scholar 

  31. Stephens RL, Clark G (1981) Phase II with mitoxantrone in non-hematologic malignancies. NCI-EORTC Symposium on New Drugs, Abstract 36

  32. Sternberg JJ, Bracken RB, Handel PB, Johnson DE (1977) Combination chemotherapy (CISCA) for advanced urinary tract carcinoma. A preliminary report. JAMA 238: 2282–2287

    Google Scholar 

  33. Stoter G (1982) Chemotherapy of advanced bladder cancer. Abstracts of the European Society for Therapeutic Radiology and Oncology 70

  34. Troner MB, Hemstreet GP III (1981) Cyclophosphamide, doxorubicin, and cisplatin (CAP) in the treatment of urothelial malignancy: A pilot study of the Southeastern Cancer Study Group. Cancer Treat Rep 65: 29–32

    Google Scholar 

  35. Turner AG, Hendry WF, Williams GB, Bloom HJG (1977) The treatment of advanced bladder cancer with methotrexate. Br J Urol 49: 673–678

    Google Scholar 

  36. Veenema RJ, Harisiadis L, Chang C, Puchner P, Romas N, Wechsler M, Guttman R (1981) Bladder carcinoma: Preliminary external radiotherapy used as a means for selecting complete treatment. In: Connolly JG (ed) Carcinoma of the bladder. Raven Press, New York, pp 183–191

    Google Scholar 

  37. Von Hoff DD, Pollard E, Kuhn J, Murray E, Coltman CA Jr (1980) Phase I clinical investigation of 1,4-dihydroxy-5,8-bis[a2-(2-hydroxyethyl)amino (ethyl amino)]-9,10-anthracenedione dihydrochloride (NSC 301739), a new anthracenedione. Cancer Res 40: 1516

    Google Scholar 

  38. Wallace DM, Bloom HJG (1976) The management of deeply infiltrating (T3) bladder carcinoma: controlled trial of radical radiotherapy vs pre-operative radiotherapy and radical cystectomy (first report). Br J Urol 48: 587–594

    Google Scholar 

  39. Wallace RE, Murdock KC, Angier RB, Durr FE (1979) Activity of a novel anthracenedione, 1,4-dihydroxy-5,8bis(((2-2-hydroxyethyl) aminoethylamino))-9,10-anthracenedione dihydrochloride, against experimental tumors in mice. Cancer Res 39: 1570–1574

    Google Scholar 

  40. Weinstein SH, Schmidt JD (1976) Doxorubicin chemotherapy in advanced transitional cell carcinoma. Urology 8: 336–341

    Google Scholar 

  41. Werf-Messing B van der (1981) Combined-modality treatment of bladder cancer at the Rotterdam Radiotherapy Institute. In: Connolly JG (ed) Carcinoma of the bladder. Raven Press, New York, pp 219–226

    Google Scholar 

  42. Whitmore WF Jr (1981a) Integrated irradiation and cystectomy for bladder cancer. In: Connolly JG (ed) Carcinoma of the bladder. Raven Press, New York, pp 235–249

    Google Scholar 

  43. Whitmore WF Jr (1981b) Pre-operative low-dose radiotherapy and cystectomy. In: Oliver RTD, Hendry WF, Bloom HJG (eds) Bladder cancer — Principles of combinaton therapy. Butterworths, London, pp 175–182

    Google Scholar 

  44. Williams G, Jones MA, Trott PA, Bloom HJG (1981) Carcinoma of the bladder treated by local interstitial irradiation. In: Oliver RTD, Hendry WF, Bloom HJG (eds) Bladder cancer — Principles of combination therapy. Butterworths, London, pp 117–126

    Google Scholar 

  45. Williams SD, Donohue JP, Einhorn LH (1979) Advanced bladder cancer: Therapy with cis-dichlorodiammineplatinum (II), Adriamycin, and 5-fluorouracil. Cancer Treat Rep 63: 1573–1576

    Google Scholar 

  46. Wizenberg NJ (1979) Invasive bladder cancer — Definitive irradiation and salvage cystectomy. Semin Oncol 6: 229–235

    Google Scholar 

  47. Yagoda A (1977) Future implications of phase 2 chemotherapy trials in ninety-five patients with measurable advanced bladder cancer. Cancer Res 37: 2775–2780

    Google Scholar 

  48. Yagoda A, Watson RC, Kemeny N, Barzell WE, Grabstald H, Whitmore WF (1978) Diamminedichloride platinum II and cyclophosphamide in the treatment of advanced urothelial cancer. Cancer 41: 2121–2130

    Google Scholar 

  49. Zee-Cheng RKY, Cheng CC (1978) Antineoplastic agents. Structure activity relationship study of bis (substituted aminoalkylamino) anthraquinones. J Med Chem 21: 291–294

    Google Scholar 

  50. Zingg EJ, Zeltner T (1980) Partial cystectomy. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum Press, London New York, pp 201–205

    Google Scholar 

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Smith, P.H., Child, J.A., Mulder, J.H. et al. Cooperative studies of systemic chemotherapy. Cancer Chemother. Pharmacol. 11 (Suppl 1), S25–S31 (1983). https://doi.org/10.1007/BF00256713

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