Abstract
A visualization of the bone marrow beside that of the spleen was obtained with 99mTc-labeled N-ethylmaleimide (NEM) damaged erythrocytes in a patient with systemic lupus erythematosus. This phenomenon could be produced both with autologous and homologous red cells. The patient's NEM-damaged erythrocytes given to a healthy patient did not produce a visualization of the marrow. Such an observation was not present in a series of healthy persons and patients with different disorders to whom labeled and damaged erythrocytes were administered, and has not been reported in the literature so far.
Similar content being viewed by others
References
Atkins H, Eckelman W, Richards P, Hauser W (1971) Technetium-labeled red blood cells. JNM 12:22–24
Frank MM, Hamburger MJ, Kimberly RP, Lawley TJ, Plotz PH, Thomas J (1979) Defective reticulo-endothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 300:518–523
Hamilton RG, Alderson RO, Harwig JF, Siegel BA (1976) Splenic imaging with 99mTc-labeled erythrocytes: A comparative study of cell-damaging methods. JNM 17:1039–1043
Jacob HS, Jandl JH (1961) Effect of membrane sulfhydryl deficiency and survival of red cells. Clin Res 9:162
Kimber RJ, Lander H, Robson HN (1965) The sequestration of NEM-treated red cells in normal and abnormal subjects: A test of splenic uptake function. J Lab Clin Med 65:951–966
Korubin V, Maisey MN, McIntyre PA (1972) Evaluation of technetium red-cells for determination of red cell volume in man. JNM 13:760–762
Korubin-Dolgova V, Bogdanova V, Simova N (1980) Diagnosis of hyposplenism by radioisotope method. Radiol Iugosl 14:363–365
Nelp WB (1975) An evaluation of colloids for RES function studies. In: Subramanian G, Rhodes BA, Cooper JF (eds) Radiopharmaceuticals, Society of Nuclear Medicine, New York, pp 349–355
Wagner HN, Razzak MA, Gaertner RA, Caine WP, Feacin OT (1979) Defective reticulo endothelial system function in rheumatoid arthritis. Lancet 1:1311–1314
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dolgova-Korubin, V., Simova, N. Unusual bone marrow visualization with 99mTc-damaged erythrocytes. Eur J Nucl Med 7, 240–241 (1982). https://doi.org/10.1007/BF00256473
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256473