Skip to main content

Advertisement

SpringerLink
Log in

Tropolone: A lipid solubilizing agent for cationic metals

  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Lipid soluble agents which chelate radioactive cations have several potential uses in nuclear medicine including: brain imaging, labeling of blood elements, and identifying fatty infiltration of organs. A tropolone-gallium complex has been characterized by the determination of in vitro partition ratios correlated with in vivo organ distribution in the rat. Partition ratios were determined for gallium-67 citrate, indium-114m chloride, and iron-59 chloride cations complexed with tropolone in chloroform+water, octanol+water, olive oil+water, and olive oil+plasma two-phased systems. Tropolone proved to be highly effective in the lipid solubilization of these metal cations. Distribution studies in animals of these cations complexed with tropolone demonstrated an increased concentration of these cation complexes in tissues of high lipid content when compared with appropriate controls.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ahmad M, Witztum KF, Fletcher JW, Hendershott LR, Klos D, George EA, Donati RM, Jacobs A, Cerami A (1977) Xenon-133 accumulation in hepatic steatosis. JNM 18:881–885

    Google Scholar 

  • Grady RW, Graziano JH, White GP, Jacobs A, Cerami A (1978) The development of new iron-chelating drugs. II. J Pharmacol Exp Ther 205:757–765

    Google Scholar 

  • McAfee JG, Thakur ML (1976) Survey of radioactive agents for in vitro labeling of phagocytic leukocytes. JNM 17:480–487

    Google Scholar 

  • Oldendorf WH (1974) Lipid solubility and drug penetration of the blood brain barrier. Proc Soc Exp Biol Med 147:813–816

    Google Scholar 

  • Pitt CG, Gupta G (1975) The design and synthesis of chelating agents for the treatment of iron overload in Cooley's Anemia. Proceedings of symposium on development of iron chelators for clinical use. pp 137–168

  • Pitt CG, Gupta G, Estes WE, Rosenkrantz H, Metterville JJ, Crumbliss AL, Palmer RA, Nordquest KW, Sprinklehardy KA, Whitcomb DR, Byers BR, Arceneaux JEL, Gaines GG, Sciortino CV (1979) The selection and evaluation of new chelating agents for the treatment of iron overload. J Pharmacol Exp Ther 20:12–18

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. VA Medical Center, Saint Louis, Missouri, USA

    Lynn Hendershott, Rita Gentilcore, Frederick Ordway, James Fletcher & Robert Donati

  2. Saint Louis University, Saint Louis, Missouri, USA

    Lynn Hendershott, Rita Gentilcore, Frederick Ordway, James Fletcher & Robert Donati

Authors
  1. Lynn Hendershott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rita Gentilcore
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Frederick Ordway
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert Donati
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hendershott, L., Gentilcore, R., Ordway, F. et al. Tropolone: A lipid solubilizing agent for cationic metals. Eur J Nucl Med 7, 234–236 (1982). https://doi.org/10.1007/BF00256471

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00256471

Keywords

Search

Navigation