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Urinary excretion of urate in patients with calcium oxalate stone disease

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Summary

The diurnal variation in excretion and concentration of urinary urate was studied in 31 patients with calcium oxalate stone disease. Urate excretion was highest during the day-time, decreased in the evening and was low during the night. Meal-related peaks were observed. The concentration of urate reached the highest levels during the morning hours and, attributable to a low pH in morning urine, most samples were at this time super-saturated with respect to uric acid. In addition, many urines appeared to be at high risk of exceeding the uric acid formation product. Concerning the ion-activity product of sodium urate, supersaturated samples were frequently found, but the risk of exceeding the formation product for sodium urate at a normal urate excretion was apparently low.

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Authors and Affiliations

  1. Department of Urology, University Hospital, Linköping, Sweden

    H.-G. Tiselius

  2. Department of Clinical Chemistry, University Hospital, Linköping, Sweden

    L. Larsson

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  1. H.-G. Tiselius
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  2. L. Larsson
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Tiselius, HG., Larsson, L. Urinary excretion of urate in patients with calcium oxalate stone disease. Urol. Res. 11, 279–283 (1983). https://doi.org/10.1007/BF00256347

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  • DOI: https://doi.org/10.1007/BF00256347

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