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Keyhole-Limpet Haemocyanin (KLH) immunotherapy of murine transitional cell carcinoma

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Summary

The antigenicity of transitional cell carcinoma of the bladder has stimulated the search for effective immunotherapeutic agents in the treatment of this disease. Non-specific immunotherapy with local (intravesical/intralesional) and systemic Keyhole Limpet Haemocyanin (KLH) in a FANFT induced murine bladder tumor model was studied. Results showed no difference between control or treated groups in either tumor growth or animal survival.

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References

  1. Bubenik J, Perlmann P, Helmstein K, Moberger G (1970) Cellular and humoral immune responses to human urinary bladder carcinomas. Int J Cancer 5:310

    Google Scholar 

  2. Camacho F, Pinsky C, Kerr D, Whitmore WF, Oettgen H (1980) Treatment of superficial bladder cancer with intravesical BCG. Immunotherapy of cancer: present status of trials in man (Abstract). National Cancer Institute, Bethesda, Md, April 28–30

    Google Scholar 

  3. Curtis JE, Hersh EM, Butler WT, Rossen RD (1971) Antigen dose in the human immune response. Dose response relationships in the human immune response to keyhole limpet haemocyanin. J Lab Clin Med 78:61

    Google Scholar 

  4. Curtis JE, Hersh EM, Harris JE, McBride C, Freireich EJ (1970) The human primary immune response to keyhole limpet haemocyanin: interrelationships of delayed hypersensitivity, antibody response and in vitro blast transformation. Clin Exp Immunol 6:473

    Google Scholar 

  5. Curtis JE, Hersh EM (1972) The human secondary immune response to keyhole limpet haemocyanin. Clin Exp Immunol 10:171

    Google Scholar 

  6. Daly JJ, Prout GR, Ahl CA (1973) Demonstration of specific antigen in N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl]formamide induced rat bladder tumor. J Urol 109:253

    Google Scholar 

  7. Feneley RCL, Eckert H, Riddell AG, Symes MO, Tribe CR (1974) The treatment of advanced bladder cancer with sensitized pig lymphocytes. Br J Surg 61:825

    Google Scholar 

  8. Herr HW, Kemery N, Yagoda A, Whitmore WF (1978) Poly (I.C.) immunotherapy in patients with papillomas or superficial carcinomas of the bladder. Natl Cancer Inst Monogr 49:325

    Google Scholar 

  9. Kagawa S, Ogura K, Kurakowa K, Vyama K (1979) Immunological evaluation of a streptococcal preparation (OK-432) in treatment of bladder carcinoma. J Urol 122:467

    Google Scholar 

  10. Klippel KF, Paulini G, Hutschenreiter G (1977) The effect of keyhole limpet haemocyanin (KLH) on the rat bladder. Cancer Immunol Immunother 3:65

    Google Scholar 

  11. Lamm DL, Reyna JA, Reichert DF (1981) Keyhole limpet haemocyanin and immune ribonucleic acid immunotherapy of murine transitional cell carcinoma. Urol Res 9:227

    Google Scholar 

  12. Lamm DL, Harris SC, Gittes RF (1977) Bacillus calmetteguerin and dinitrochlorobenzene immunotherapy of chemically induced bladder tumors. Invest Urol 14:369

    Google Scholar 

  13. Lamm DL, Reichert DF, Radwin HM, Thor DE (1979) Bacillus calmette-guerin immunotherapy of the cancer-contaminated wound. J Surg Res 27:14

    Google Scholar 

  14. Lamm DL, Thor DE, Harris SC, Stogdill VD, Radwin HW (1980) Intravesical and percutaneous BCG immunotherapy of recurrent superficial bladder cancer. Immunotherapy of cancer: present status of trials in man (Abstract). National Cancer Institute, Bethesda, Md, April 28–30

    Google Scholar 

  15. Lavergne JA, Lamm DL, Radwin HM, Harrington JT (1979) Leukocyte migration inhibition in vitro in bladder carcinoma. Cancer Res 39:1985

    Google Scholar 

  16. Morales A, Eidinger D, Bruce AW (1976) Intracavitary bacillus calmette-guerin in the treatment of superficial bladder tumors. J Urol 116:180

    Google Scholar 

  17. Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin North Am 3:13

    Google Scholar 

  18. Olsson CA, Chute R, Rao CN (1974) Immunologic reduction of bladder cancer recurrence rate. J Urol 111–173

  19. O'Toole C, Stejskal V, Perlmann P, Karlsson M (1974) Lymphoid cells mediating tumor specific cytotoxicity to carcinoma of the urinary bladder. J Exp Med 139:457

    Google Scholar 

  20. Taranger LA, Chapman WH, Hellstrom I, Hellstrom KE (1972) Immunological studies on urinary bladder tumors of rats and mice. Science 176:1337

    Google Scholar 

  21. Weldon TE, Soloway MS (1975) Susceptibility of urothelium to neoplastic cellular implantation. Urology 5:824

    Google Scholar 

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Walsh, W.G., Tomashefsky, P., Olsson, C.A. et al. Keyhole-Limpet Haemocyanin (KLH) immunotherapy of murine transitional cell carcinoma. Urol. Res. 11, 263–265 (1983). https://doi.org/10.1007/BF00256343

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  • DOI: https://doi.org/10.1007/BF00256343

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