Summary
Tween 80 was shown to enhance significantly the cytotoxic activities of the four drugs (adriamycin, epodyl, mitomycin-c, thiotepa) most frequently administered intravesically to treat superficial bladder cancer. The colony forming ability of a human bladder cancer cell line, RT112, was measured following a 1 h exposure to each of the four drugs both alone and in combination with 0.1% and 0.3% Tween 80. Cell survival was not reduced by 0.1% Tween 80 alone. We conclude that the combination of Tween 80 with these drugs might increase the therapeutic index of intravesical chemotherapy.
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Parris, C.N., Masters, J.R.W., Walker, M.C. et al. Intravesical chemotherapy: Combination with tween 80 increases cytotoxicity in vitro. Urol. Res. 15, 17–20 (1987). https://doi.org/10.1007/BF00256329
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DOI: https://doi.org/10.1007/BF00256329