Summary
The radioisotope renogram and renal clearances using 131I-Hippurate were studied during experimentally controlled renal perfusion. In the first series of experiments, renograms were recorded during variations in renal blood flow produced by an extracorporeal pump circuit. There was a close correlation between renal blood flow and renogram parameters. These characteristics were also related to urine flow rates. —In the second series of experiments, unilateral renal damage was produced either by ischaemia or obstruction. Individual clearances using 131I-Hippurate and the gamma camera were compared with standard clearances obtained during a steady state. There was a close correlation between these methods and the results emphasise the importance of subtracting, background radioactivity. — It is concluded that the main value of the renogram is to provide a left to right comparison of renal tubular function whereas the value of corrected 131I-Hippuran clearances is to provide an absolute measure of individual effective renal plasma flow.
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References
Britton, K. E., Brown, N. J. G.: Clinical renography. London: Lloyd-Luke 1971
Farmelant, M. H., Sachs, C., Burrows, B. A.: Prognostic value of radioisotope renal function studies for selecting patients with renal arterial stenosis for surgery. J. nucl. Med. 11, 743 (1970)
Hünermann, B., Albert, J. P., Weißbach, L., Winkler, C.: Die katheterlose, seitengetrennte Bestimmung der renalen Clearance mit EPA-Korrektur. Espelkamp: Picker NUC Bulletin 2/73
Hünermann, B., Weißbach, L., Wesener, K., Winkler, C.: Tierexperimentelle Untersuchungen zur katheterlosen, seitengetrennten J131-Hippuran-Clearance mit EPA-Korrektur unter Verwendung eines Kamera-Computersystems. 11th Ann. Conf. Nuclearmed. Ass., Athen 1973. Stuttgart: Schattauer (in press)
Magnusson G.: Kidney function studies with 131I-tagged sodium ortho-iodo-hippurate. Acta med. scand. Suppl. vol. 378, 171 (1962)
Niedermayer, W.: Das Verhalten der Nierendurchblutung und des renalen Strömungswiderstandes bei arterieller Gegenpulsation. Z. Kreisl.-Forsch. 61, 1057 (1972)
Oberhausen, E.: Bestimmung der Nierenclearance mit dem Ganzkörperzähler. In: Höfer, R.: Nierenclearance. Frankfurt: Hoechst 1968
Oberhausen E., Berberich, R., Heinrich, W.: Nuclearmedizinische Bestimmung der Nierenclearance. Electro Medica 2, 42 (1972)
Short, M. D., Glass, H. I., Chisholm, G. D., Vernon, P., Silvester, D. J.: Gammacamera renography using 123I-Hippuran. Brit. J. Radiol. 46, 289 (1973)
Wax, S. H., McDonald, D. F.: Analysis of the I-131 sodium o-iodohippurate renogram. J. Amer. med. Ass. 13, 140 (1962)
Weidmann, P., Knopp, R., Schulte, P., Winkler, C., Werning, C., Siegenthaler, W.: Radionephrographie mit Subtraktion der extraparenchymalen Aktivität. Fortschr. Röntgenstr. 116, 77 (1972)
Zum Winkel, K.: Nierendiagnostik mit Radioisotopen. Stuttgart: Thieme 1964
Winkler, C.: Radionuklid-Diagnostik mit Szintillationskamera und Computermethoden. Kerntechnik 11, 328 (1969)
Winter, C. C.: Further experiences with radioisotope renogram. Amer. J. Roentgenol. 82, 862 (1959)
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This research was undertaken with the support of the Federal Ministry for Research and Technology
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Hünermann, B., Weißbach, L. & Zwicker, H. The renogram and individual 131I-Hippuran clearances in experimentally controlled renal perfusion. Urol. Res. 3, 81–85 (1975). https://doi.org/10.1007/BF00256186
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DOI: https://doi.org/10.1007/BF00256186