Summary
Data on the excretion of Tamm-Horsfall protein (THP) in subjects living in an area of Balkan endemic nephropathy (BEN) are reported. The study subjects were divided into groups as follows: diseased, suspect, “at risk” and others, according to previously adopted criteria. The THP excretion in “at risk” subjects was found to be significantly higher as compared to control subjects. The difference between these two groups could not be registered by any other clinical or laboratory diagnostic methods. No difference in the excretion of THP was observed between the groups of others and control subjects. According to the results obtained, the excretion of THP may be considered a possibly useful additional diagnostic test for the detection of subjects with the latent, early subclinical phase of BEN. On the other hand, the data obtained shed some more light on the still obscure pathogenesis and natural history of BEN.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Čvorišćec D (1980) Tamm-Horsfall protein and its clinical significance. Diab Croat 9:405
Čvorišćec D, Radonić M, Čeović S, Aleraj B (1983) Characteristics of proteinuria in endemic nephropathy. J Clin Chem Biochem 21:569
Čvorišćec D, Stavljenić A (1984) Tamm-Horsfall protein-determination and reference values. Acta Pharm Jugosl 34:43
Čvorišćec D, Stavljenić A, Radonić M (1985) Tamm-Horsfall protein in Balkan endemic nephropathy. J Clin Chem Biochem 23:177
Čvorišćec D, Stavljenić A, Radonić M (1986) Relationship between tubular and Tamm-Horsfall proteinuria in Balkan endemic nephropathy. Nephron 42:152
Danilović V, Gjurišić M, Mokranjac M, Stojimirović B, Živojinović B, Živojinović J, Stojaković P (1958) Porodična obolenja bubrega u selu Šopić izazvana hroničnom intoksikacijom olovom. Srp Arh Celok Lek 86:1409
Grant AMS, Baker LRI, Neuberger A (1973) Urinary Tamm-Horsfall glycoprotein in certain kidney diseases and its content in renal and bladder calculi. Clin Sci 44:377
Hall PV, Vasiljević M (1973) Beta-2-microglobulin excretion as an index of renal tubular disorder in Balkan endemic nephropathy. J Lab Clin Med 81:897
Hoyer JR, Seiler MW (1979) Pathophysiology of Tamm-Horsfall protein. Kidney Int 16:279
Hrabar A, Aleraj B, Borčić B, Čeović S (1979) Association of some depidemiologic variables with LMW test findings in the population of endemic areas of Brod. Posavina. Proceedings of the 4th Symposium on Enedemic (Balkan) Nephropathy, Niš, p 233
Karlsson FA, Lenkei R (1977) Urinary excretion of albumin and beta-2-microglobulin in a population from an area where Balkan nephropathy is endemic. Scand J Clin Lab Invest 37:169
Lenkei R, Moraru I, Passare G, Melencu M, Parvulescu G (1972) Proteinuria in the Balkan endemic nephropathy. Bulgarian Academy of Sciences, Proceedings of the 2nd Symposium on Endemic Nephropathy, Sofia, p 42
Mallick NP, Short CD, Hunt LP (1987) How far since Ellis? Nephron 46:114
Puhlev A, Astrug A, Popov N, Dočev D (1960) Klinični proučavania vrhu endemična nefrit. Medicina i fizkultura, Sofia, p 7
Radonić M, Radošević Z, Županić V (1966) Endemic nephropathy in Yugoslavia. The kidney. Williams and Wilkins, Baltimore, p 503
Radonić M, Radošević Z, Keler-Bačoka M, Mihelčić N, Čeović S (1975) Ispitivanje mokraće bolesnika i prividno zdravih osoba iz područja endemske nefropatije metodama elektroforeze i imunoelektroforeze. Lijec Vjesn 97:547
Radonić M (1978) Beta-2-microglobulin in Balkan endemic nephropathy. Path Biol 26:317
Radonić M, Čvorišćec D, Stavljenić A, Sertić J, Boršo G (1987) Tamm-Horsfall protein and antibodies to Tamm-Horsfall protein in the study of renal diseases. In: Kovačević Z, Guder WG (eds) Molecular nephrology. de Gruyter, Berlin New York, p 369
Radonić M, Radošević Z (in press) Clinical features of Balkan endemic nephropathy. Arh Hig Rada [Suppl]
Radonić M, Čvorišćec D, Boršo G, Stavljenić A, Čeović S (in press) Detection of subclinical phases of endemic Balkan nephropathy by the determination of Tamm-Horsfall protein in urine. Proceedings of the VIth Symposium on Balkan Endemic Nephropathy, Niš
Radošević Z, Radonić M, Horvat Z (1959) Klinička zapa-anja o endemskoj nefropatiji u Hrvatskoj. Lijec Vjesn 81:445
Radošević Z, Radonić M, Traeger J, Manuel Y, Revillard JP (1968) Etudes électrophoretiques de la protéin urie de 31 sujects croates vivant en pays de néphropathie endemique. J Urol Nephrol 74:703
Stoica Gh, Bruckner I, Constantin D, Michiu V (1969) Urine proteins in renal disease with special reference to endemic nephropathy. Rev Roum Med Interne 6:323
Tamm I, Horsfall FL Jr (1950) Characterization and separation of an inhibitor of viral hemagglutination present in urine. Proc Soc Exp Med 74:108
Tančev I, Evstatiev P, Dorosiev D, Penčeva Ž, Cvetkov G (1956) Proučavania na nefritite ve Vračanska okolija. Savremena Medicina 7:14
WHO Planning Conference on Endemic Nephropathy (1964) Dubrovnik
WHO Meeting of Investigators on Endemic Nephropathy (1974) Beograd Lazarevac, Final Report
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Radonic, M., Čvorišcec, D., Boršo, G. et al. Tamm-horsfall protein determination in Balkan endemic nephropathy. Urol. Res. 16, 377–380 (1988). https://doi.org/10.1007/BF00256046
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00256046