Abstract
99mTc-labelled derivatives of aminomethane diphosphonic acid, general formula: R1R2N-CR3 [PO(OH)2]2, as well as hydroxyethane diphosphonic acid and hydroxypropane monophosphonic acid were investigated with regard to their suitability for skeleton scintigraphy. Bone accumulation was related to chemical structure. It was concluded from the experiments that compounds able to form enols are accumulated to a higher degree and that big substituents influence the affinity to bone negatively by steric hindrance.
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References
Castronovo FP, Callahan RJ (1972) New bone scanning agent: Tc-99m labelled 1-hydroxy-ethylidene-1, 1-disodiumphosphonate. J Nucl Med 13:823
Castronovo FP (1974) Method for synthesis of 1-hydroxy-ethylidene-1, 1-disodiumphosphonate, a skeletal seeking radiopharmaceutical labelled with Tc-99m. J Nucl Med 15:127
Hosain P, Spencer RP, Ahlquist KJ (1978) Bone accumulation of the Tc-99m-complex of carbamyl phosphate and its analogs. J Nucl Med 19:530
Kung H, Ackerhalt R, Blau M (1977) Are two phosphate groups necessary for bone localization of Tc-99m complexes (abstr). J Nucl Med 18:624
Subramanian G, Blair RJ, Kallfelz EA, Thomas FD, McAfee JG (1973) Tc-99m-MDP (methylene diphosphonate): A superior agent for skeletal imaging (abstr). J Nucl Med 14:640
Subramanian G, Blair RJ, Thomas FD, Kallfelz EA (1975) Tc-99m-methylene diphosphonate—a superior agent for skeletal imaging: Comparison with other Tc-99m-complexes. J Nucl Med 16:744
Subramanian G, McAfee JG, Blair RJ, Thomas FD (1976) Radiopharmaceuticals for bone and bone-marrow imaging. IAEA-SM 210/309, vol II. Los Angeles, Okt. 1976, pp 83–104
Unterspann S (1976) Experimental examinations of the suitability of organoaminomethane-bis-phosphonic acids for bone scintigraphy by means of Tc-99m in animals. Eur J Nucl Med 1:151
Unterspann S (1977) Zusmmmenhang zwischen chemischer Struktur der Derivate der Aminomethandiphosphonsäure und Knochenanreicherung der Tc-99m-Komplexe. Radiobiol Radiother 18:762 Abstr
Wang TST, Mojdehi GE, Fawwaz RA, Johnson PM (1979) Study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids. J Nucl Med 20:1066
Yano Y, McRae J, van Dyke DC, Anger HO (1972) Tc-99m-labelled Sn-II-diphosphonate: A bone scanning agent (abstr). J Nucl Med 13:480
Yano Y, McRae J, van Dyke DC, Anger HO (1973) Tc-99m-labelled stannous ethan-1-hydroxy-1,1-diphosphonate: A new bone scanning agent. J Nucl Med 14:73
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Unterspann, S., Finck, W. Chemical structure and pharmacokinetics of 99mTc-labelled aminomethane diphosphonic acid derivatives. Eur J Nucl Med 6, 527–530 (1981). https://doi.org/10.1007/BF00255886
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DOI: https://doi.org/10.1007/BF00255886