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Hepatobiliary imaging using Tc-pyridoxylideneglutamate in the diagnosis of obstructive jaundice


In 77 of 114 consecutive patients with suspected hepatobiliary disease undergoing cholescintigraphy a firm clinical or operative diagnosis was possible. These patients were classified as normal, or as having extra-hepatic biliary obstruction (partial or complete) or hepatocellular disease. On a double-blind basis cholescintigraphy correctly interpreted 18 of 20 (90%) normal controls, 12 of 14 (86%) of those with partial obstruction, 16 of 16 (100%) of those with complete obstruction and 23 of 27 (85%) of those with hepatocellular disease giving an overall diagnostic accuracy of 69 of 77 (90%). There were no complications or toxic reactions. Ninety-three percent of patients with biliary obstruction (sensitivity) and 87% of those without biliary obstruction (specificity) were correctly diagnosed. Cholescintigraphy is a non-invasive, cheap and reliable investigation which can be used in the presence of icterus to discriminate between patients with and without extra-hepatic biliary obstruction. In contrast to grey scale ultrasonography the production and interpretation of scans are simple. Moreover cholescintigraphy adds a functional element to the investigation of liver disease.

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Correspondence to David N. Clarke.

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Clarke, D.N., Sharp, P.F., Brunt, P.W. et al. Hepatobiliary imaging using Tc-pyridoxylideneglutamate in the diagnosis of obstructive jaundice. Eur J Nucl Med 7, 370–375 (1982).

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  • Liver Disease
  • Nuclear Medicine
  • Normal Control
  • Diagnostic Accuracy
  • Grey Scale