Summary
In benign hyperplasia marked β-glucuronidase and N-acetyl-β-glucosaminidase activity was seen in the prostatic epithelium whereas the reactions for 5 other glycosidases were only slight or negative. The intensity of the reaction for the glycosidases in prostatic carcinoma was dependent upon the degree of the differentiation. The possible importance of glycosidases for the invasiveness of prostatic carcinoma is briefly discussed.
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References
Brandes, D., Bourne, G. H.: Histochemistry of some aspects of prostate pathology. Biology of the prostate and related tissues. National Cancer Institute Monographs 12, 29–91 (1963)
Conchie, J., Findlay, J., Levvy, G. A.: Mammalian glycosidases distribution in the body. Biochemical Journal 711, 318 (1959)
Gossrau, R.: Über den histochemischen Nachweis der β-Glucuronidase, α-Mannosidase und α-Galactosidase mit 1-Naphthylglykosiden. Histochemie 36, 367 (1973)
Gossrau, R.: Über die Eignung von Naphthyl-α-L-Fucosiden zur Untersuchung der α-L-Fucosidasen. Histochemistry 52, 259 (1977)
Györkey, F.: Some Aspects of Cancer of the Prostate Gland. Methods in Cancer Research. Vol. 10, Ed. H. Busch. New York: Academic Press 1973
Hayashi, M., Nakajima, Y., Fishman, W. H.: The cytoplasmic demonstration of β-Glucuronidase employing Natphol-AS-BI-Glucosaminide and Hexazonium Pararosanilin; a preliminary report. Journal of Histochemistry and Cytochemistry 12, 293 (1964)
Hayashi, M.: Histochemical demonstration of N-Acetyl-β-Glucosaminidase employing Naphthol-AS-BI-N-Acetyl-β-Glucosaminid as substrate. Journal of Histochemistry and Cytochemistry 13, 355 (1965)
Kastendieck, H., Altenähr, E., Burkhardt, P.: Elektronenmikroskopische Untersuchungen zur Zelldifferenzierung in Prostata-Carcinomen. Virchows Archiv; A: Pathological Anatomy and Histology 361, 241 (1973)
Kastendieck, H., Altenähr, E.: Cyto- and histomorphogenesis of the prostate carcinome. Virchows Archiv; A: Pathological Anatomy and Histology 370, 207 (1976)
Kirchheim, D., Brandes, D., Bacon, R. L.: Fine Structure and Cytochemistry of Human Prostatic Carcinoma. Male Accessory Sex Organs. Ed. by D. Brandes. New York: Academic Press 1974
Lojda, Z., Kraml, J.: Indigogenic methods for Glycosidases III. An inproved method with 4-Cl-5Br-3-Intolyl-β-D-Fucoside and its application in studies of enzymes in the intestine, kidney and other tissues. Histochemie 25, 195 (1977)
Riede, U. N., Staubesand, J.: A unifying concept for the role of matrix vesicles and lysosomes in the formal pathogenesis of diseases of connective tissues and blood vessels. Beiträge zur Pathologie 160, 3 (1977)
Rutenburg, A. M., Rutenburg, S. M., Mones, B., Teaque, R., Seligman, A. M.: Histochemical demonstration of β-D-Galactosidase in the rat. Journal of Histochemistry and Cytochemistry 6, 122 (1958)
Sinowatz, F., Weber, P., Skolek-Winnisch, R., Mossig, H.: Histotopik von Glykosidasen in der Prostata des Menschen. (In preparation)
Wynder, E. L., Mabuchi, K., Whitmore, W. F.: Epidemiology of cancer of the prostate. Cancer 28, 344 (1971)
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Sinowatz, F., Weber, P., Gasser, G. et al. A histochemical study of glycosidases in benign prostatic hyperplasia and in prostatic carcinoma in the human. Urol. Res. 6, 103–107 (1978). https://doi.org/10.1007/BF00255581
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DOI: https://doi.org/10.1007/BF00255581