Skip to main content
SpringerLink
Log in

Diphenylamine-induced renal lesions in the chicken

  • Originals
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

Chronic intoxication with diphenylamine (DPA), which causes a cystic kidney disease in the rat and the guinea-pig, caused degeneration of the renal tubular epithelium in the chicken. This was similar to but much more serious than that preceding the formation of cysts in the rodents, but did not actually result in cyst formation, probably because of the high mortality rate observed in the birds even at this early stage. In the chicken until now it had been possible to obtain a pattern of renal cysts only with polychlorinated biphenyls (PCB) which also induce the “chick oedema” syndrome. The renal lesions due to DPA in the chicken were similar to those produced by PCB, but were not accompanied by oedema, which suggests that “chick oedema” caused by PCB is not due to renal insufficiency. The differences in the renal lesions noted in the various animal species give credit to the hypothesis that DPA may have two effects on the tubular epitelium, one stimulating cell proliferation and one leading to degeneration. Cysts may be formed only in those species in which there is cell proliferation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Carone, F. A., Rowland, R. G., Perlman, S. G., Ganotte, C. E.: The pathogenesis of drug-induced renal cystic disease. Kidney international 5, 411 (1974)

    Google Scholar 

  2. Combined Reports on regular dialysis and transplantation in Europe. I–VI, 1970–75; Proc. European Dialysis and Transplant Association, vol. 8–13; 1971–76

  3. Crocker, J. F. S., Brown, D. M., Borch, R. F., Vernier, R. L.: Renal cystic disease induced in newborn rats by diphenylamine derivatives. American Journal of Pathology 66, 343 (1972)

    Google Scholar 

  4. Darmady, E. M., Offer, J., Woodhouse, M. A.: Toxic metabolic defect in polycystic disease of kidney. Lancet I, 547 (1970)

    Google Scholar 

  5. Gardner, K. D. Jr, Solomon, S., Fitzgerrel, W. W., Evan, A. P.: Function and structure in the diphenylamine-exposed kidney. Journal of Clinical Investigation 57, 796 (1976)

    Google Scholar 

  6. Kime, S. W. jr, McNamara, J. J., Luse, S., Farmer, S., Silbert, C., Bricker, N. S.: Experimental polycystic renal disease in rats. Journal of Laboratory and Clinical Medicine 60, 64 (1962)

    Google Scholar 

  7. McCune, E. L., Savage, J. E., O'Dell, B. L.: Hydropericardium and ascites in chicks fed a chlorinated hydrocarbon. Poultry Science 41, 295 (1962)

    Google Scholar 

  8. McGeoch, J. E. M., Darmady, E. M.: Polycystic disease of kidney, liver and pancreas; a possible pathogenesis. Journal of Pathology 119, 221 (1976)

    Google Scholar 

  9. Morris, R. C. jr, McInnes, R. R., Epstein, C. I., Sebastian, A., Scriver, C. R.: Genetic and metabolic injury of the kidney. In: The Kidney. B. M. Brenner, F. C. Rector, Philadelphia: W. B. Saunders 1976

    Google Scholar 

  10. Resnick, J. S., Brown, D. M., Vernier, R. L.: Normal development and experimental models of cystic renal disease. In: Cystic Disease of the Kidney. (Ed.): K. D. Gardner, jr. New York: John Wiley & Sons 1976

    Google Scholar 

  11. Safouh, M., Crocker, J. F. S., Vernier, R. L.: Experimental cystic disease of the kidney. Laboratory Investigation 23, 392 (1970)

    CAS  PubMed  Google Scholar 

  12. Sorrentino, F.: Rene policistico sperimentale. Urologia (Treviso) 34, 525 (1967)

    Google Scholar 

  13. Sorrentino, F.: unpublished, 1971

  14. Sorrentino, F., Camocardi, S., Fella, A., Pota, A.: La teoria tossica della patogenesi delle nefropatie cistiche. Urologia (Treviso) (accepted for publication)

  15. Steg, A.: Les affections kystiques du rein de l'adulte. Rapport au 69 Congres de l'Association Française d'Urologie, Paris 1975

  16. Thomas, J. D., Cox, A. J., DeEds, F.: Kidney cysts produced by diphenylamine. Stanford Medical Bulletin 15, 90 (1957)

    Google Scholar 

  17. Thomas, J. D., Ribellin, W. E., Wilson, R. H., Keppler, D. C., DeEds, F.: Chronic toxicity of diphenylamine to albino rats. Toxicology and Applied Pharmacology 10, 362 (1967)

    Google Scholar 

  18. Vos, J. G., Koeman, J. H.: Comparative toxicologic study with polychlorinated biphenyls in chickens with special reference to porphyria, edema formation, liver necrosis and tissue residues. Toxicology and Applied Pharmacology 17, 656 (1970)

    Google Scholar 

  19. Woodhouse, M. A., Offer, J., Darmady, E. M.: Diphenylamine induced polycystic kidneys compared with human polycystic kidney: electron microscopical observations. Nephron 4, 252 (1965)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nephrology Department, A. Cardarelli Hospital, Naples, Italy

    F. Sorrentino, A. Fella & A. Pota

  2. Riviera di Chiaia 207, I-80121, Napoli, Italy

    F. Sorrentino

Authors
  1. F. Sorrentino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Fella
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Pota
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sorrentino, F., Fella, A. & Pota, A. Diphenylamine-induced renal lesions in the chicken. Urol. Res. 6, 71–75 (1978). https://doi.org/10.1007/BF00255576

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00255576

Key words

Search

Navigation