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Dosimetry of iodoantipyrine

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Abstract

Dosimetry of iodoantipyrine labeled with radioactive iodine was determined by measuring the biodistribution of 131I-iodoantipyrine in 41 female rabbits. Following administration of the radiopharmaceutical, subjects were killed at 0.5, 6, 12, 17, 24, 36, and 48 h. Organs and samples of tissues and body fluids were assayed. Results were corrected for physical decay. Exponential functions were employed to describe the time-concentration curves; representative value would be the biological half life of 9.96±0.55 h for blood. Cumulated activity estimates for 123I, 125I and 131I were then computed. Extrapolation to absorbed dose in humans followed the formulation of the Medical International Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine. The whole body absorbed doses are 7 μGray, 5 μGray and 29 μGray per MBq of 123I, 125I, and 131I administered respectively.

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Authors and Affiliations

  1. Department of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert Y. L. Chu & Sabinus Ekeh

  2. Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Garo Basmadjian

  3. Radiology Service (114), Veterans Administration Medical Center, 921 NE 13th Street, 73104, Oklahoma City, OH, USA

    Robert Y. L. Chu

Authors
  1. Robert Y. L. Chu
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  2. Sabinus Ekeh
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  3. Garo Basmadjian
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This work was supported by a research grant from the Veterans Administration

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Chu, R.Y.L., Ekeh, S. & Basmadjian, G. Dosimetry of iodoantipyrine. Eur J Nucl Med 15, 796–799 (1989). https://doi.org/10.1007/BF00255499

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  • DOI: https://doi.org/10.1007/BF00255499

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