Abstract
Left ventricular phase and amphlitude images (Fourier analysis, PAI) and factor analysis images (FAI) from gated radionuclide ventriculography were obtained in 235 patients after myocardial infarction (MI) and in 44 patients with well documented ischemic heart disease (IHD) in order to assess areas of regional left ventricular motility injury (LVMI). The sensitivity of FAI for LVMI detection was higher than with PAI (36.3% vs 22.7% in patients without MI; 76.6% vs 68% in those after anterior MI; and 53.2% vs 31.9% after posterior MI, respectively). In 2.9% of all patients PAI were unclear due to small time activity amplitudes and heart rate irregularity, whereas FAI could be easily assessed. Significantly decreased left ventricular ejection fraction was observed predominantly after anterior MI in connection with distinct signs of LVMI in a large area of anterior wall or in the anteroseptal and/or apical region. Areas of LVMI could be sharply delineated in FAI; however, in contrast to PAI, FAI is unable to distinguish between dyskinetic and akinetic regions. The use of both PAI and FAI is recommended for more detailed detection of regional LVMI in patients with IHD.
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References
Adam WE, Tarkowska A, Bitter F, Stauch M, Geffers H (1979) Equilibrium (gated) radionuclide ventriculography. Cardiovasc Interventr Radiol 2:161–173
Baillet G, Mena I, Lambert B (1987) Coronary artery disease: factor analysis assessment of the earliest myocardial perfusion of resting first pass radionuclide ventriculography. (Abstr) J Nucl Med 28:A455
Bazin JP, DiPaola R (1982) Advances in factor analysis. Application in dynamic function studies. In: Raynaud C (ed) Proceedings of the III World Congress of Nuclear Medicine and Biology, Pergamon, Paris, pp 35–38
Cavailloles F, Bazin JP, DiPaola M (1984) Factor analysis in gated cardiac studies. J Nucl Med 25:1067–1079
Fránquiz JM, Garcia-barreto D, Cardenas R (1983) A computerized method for quantitative analysis of ventricular phase distributions. Eur J Nucl Med 8:375–380
Geffers SH, Adam WE, Bitter F, Sigel H, Stauch M (1978) Radionuklid-Ventrikulographie. Grundlagen und Methoden. Nucl Med 17:206–210
Gotsman MS, Sold I, Weiss AT, Sapoznikov D, Freiman I, Shefer A, Rozenman Y, Hasin Y (1986) Left ventricular function in acute myocardial infarction: assessment by nuclear angiography. Herz 11:176–190
Kasalický J, Málek I, Kidery J, Staněk V, Fabián J, Belán A (1989) A comparison of radionuclide and contrast left ventriculography and coronary angiography in patients after myocardial infarction. Cor vasa 31:169–178
Kotzki PO, Touzery C, Munsch T, Riedinger JM, Gogou L, Piffaut P, Bidan Y, Belletier JL (1987) Fourier and factorial analysis: an objective and comparative evaluation on a cardiac phantom. J Nucl Med 13:450–455
Maddox DE, Holman BL, Wynne J, Idoine J, Parker JA, Uren R, Neill JM, Cohn PF (1978) Ejection fraction image: a noninvasive index of regional left ventricular wall motion. Am J Cardiol 41:1230–1238
Maini CL, Incalzi RA, Bonetti MG, Valle G (1986) Correlation of functional parameters derived by equilibrium radionuclide angiocardiography and left ventricular size in patients with old myocardial infarction. Eur J Nucl Med 12:60–64
Massie BM, Botvinick EH, Brundage BH, Greenberg B, Shames D, Gelberg H (1978) Relationship of regional myocardial perfusion to segmental wall motion. A physiologic basis for understanding the presence and reversibility of asynergy. Circulation 58:1154–1163
Murase K, Mochizuki T, Hamamoto K (1988) Quantitative aspect of two-factor analysis applied to radionuclide gated cardiac studies. Eur J Nucl Med 14:190–195
Neumann P, Schicha H, Tebbe U, Kreuzer H, Emrich D (1984) Analysis of left ventricular regional motility: a comparison of different methods. Eur J Nucl Med 9:205–208
Pavel DG, Briandet PA, Fang RB, Zolnierczyk K, Sychra J (1984) The normal heart: Patterns for various functional images obtained from radionuclide gated equilibrium studies. In: Deconinck F (ed) Information Processing in Medical Imaging. Nijhoff, Dordrecht, pp 250–265
Pavel DG, Sychra J, Olea E, Kahn C, Virupannavar S, Zolnierczyk K, Shanes J (1986) Factor analysis: its place in the evaluation of ventricular regional wall motion abnormalities. In: Bacharach SL (ed) Information Processing in Medical Imaging. Nijhoff, Dordrecht, pp 193–206
Philippe L, Mena I, Darcourt J, Frenck WJ (1988) Evaluation of valvular regurgitation by factor analysis of first pass angiography. J Nucl Med 29:159–167
Šámal M, Sůrová H, Maříková E, Kárný M, Dienstbier Z (1986) Improved precision, quantitative expression and enhancement of physiological factors in factor analysis of dynamic studies. In: Schmidt HAE, Ell PJ, Britton KE (eds) Proceedings of the European Nuclear Medicine Congress 1985. Nuklearmed [Suppl] 22:649–650
Šámal M, Kárný M, Sůrová H, Maříková E, Dienstbier Z (1987) Rotation to simple structure in factor analysis of dynamic radionuclide studies. Phys Med Biol 32:371–382
Šámal M, Sůrová H, Kárný M, Maříková E, Pěnička P, Dienstbier Z (1988) The reality and meaning of physiological factors. In: De Graaf CN, Viergever MA (ed) Information Processing in Medical Imaging. Plenum Press, New York, pp 499–519
Villanueva-Meyer J, Philippe L, Cordero S, Marcus CS, Mena I (1986) Use of factor analysis in the evaluation of left to right cardiac shunts. J Nucl Med 27:1442–1448
Watson DD, Smith WH, Stubbs JB, Teates CD, Beller GA (1987) Detection of endocardial motion and myocardial thickening with gated perfusion imaging. (Abstr) J Nucl Med 28:A 519
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Kasalický, J., Kidery, J., Vavrejn, B. et al. Determination of left ventricular wall motility injury by factor analysis in patients with advanced ischemic heart disease. Eur J Nucl Med 15, 767–770 (1989). https://doi.org/10.1007/BF00255494
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DOI: https://doi.org/10.1007/BF00255494