Summary
Twenty-one anti-cancer drugs have been tested for their ability to cause mutations in Salmonella typhimurium test strains in the Salmonella/microsome mutagenicity test. Nine of the 21 anticancer drugs showed this ability: cyclophosphamide, nitromin, thio-tepa, busulfan, 6-mercaptopurine, neocarzinostatin, daunomycin, adriamycin and estramustine phosphate. Seven of these 9 mutagenic drugs were injected continuously into the jugular veins of rats. Urine was collected through a cystostomy tube and tested for mutagenicity. The urine from rats treated with 6 of these 7 drugs was mutagenic. These were cyclophosphamide, nitromin, thio-tepa, neocarzinostatin, adriamycin and daunomycin.
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Pak, K., Iwasaki, T., Miyakawa, M. et al. The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs. Urol. Res. 7, 119–124 (1979). https://doi.org/10.1007/BF00254692
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DOI: https://doi.org/10.1007/BF00254692