Abstract
Single sodium channels in mouse neuroblastoma cells (N1E 115) were studied in cell-attached patches. During a series of consecutive responses to depolarizing pulses, records with and without channel opening were seen to form clusters rather than appearing randomly. The probability of finding open channels on a record seemed to increase with increasing number of channel openings. The open times of channels became shorter with increasing closed time interval measured between consecutive channel openings. Overlapping openings showed a voltage-dependent open time, in contrast to single openings which had voltage-independent open time. On the basis of these observations interaction between neighbouring sodium channels is suggested.
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Abbreviations
- RP:
-
resting potential
- OT:
-
channel open time
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Kiss, T., Nagy, K. Interaction between sodium channels in mouse neuroblastoma cells. Eur Biophys J 12, 13–18 (1985). https://doi.org/10.1007/BF00254090
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DOI: https://doi.org/10.1007/BF00254090