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Experimental regional myocardial ischaemia and myocardial uptake of potassium analogues; Intercomparison of 42K, 86Rb and 201Tl

European Journal of Nuclear Medicine volume 8, pages 288–291 (1983)Cite this article

Abstract

The uptake of 42K, 86Rb and 201Tl by non-ischaemic and ischaemic myocardium was determined in rats with coronary artery ligature lasting 10, 30, 60 and 120 min, and in control rats without ischaemia. Whereas the myocardial concentration of 201Tl and 42K in control rats was similar and higher than that of 86Rb, 201Tl was superior to the other two radionuclides due to its significantly higher accumulation in non-ischaemic myocardium and the higher ratio of non-ischaemic to ischaemic radioactivity.

The 86Rb accumulation in non-ischaemic myocardium and non-ischaemic/ischaemic ratio began to decrease from its maximum at 10 min. 201Tl, 42K and 86Rb blood levels in intact animals decreased rapidly after intravenous injection to low and nearly stabilized values at 5 min.

Na+K+-ATPase activity in the ischeamic myocardium was high in the acutely ischaemic myocardium and decreased to below control levels after 4 h of ischaemia; changes in activity could not influence the low uptake of potassium analogues in fresh ischaemic myocardium.

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References

  • Ahmed Z, Reis JL (1958) The activation and inhibition of 5-nucleotidase. Biochem J 69:386–387

    Google Scholar 

  • Albro PC, Gould KL, Westcott, RJ, Hamilton GW, Ritchie JL, Williams DL (1978) Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilatation. III. Clinical trial. Am J Cardiol 42:751–760

    Google Scholar 

  • Atkins HL, Budinger TF, Lebowitz E, Ansari AN, Greene MW, Fairchild RG, Ellis KJ (1977) Thallium-201 for medical use. Part 3: Human distribution and physical imaging. J Nucl Med 18:133–140

    Google Scholar 

  • Britten JS, Blank M (1968) Thallium activation of the (Na+−K+)-activated ATPase of rabbit kidney. Biochim Biophys Acta 159:160–166

    Google Scholar 

  • Brown HB (1966) A characterization of ouabain sensitivity of heart microsomal ATPase. Biochim Biophys Acta 120:162–165

    Google Scholar 

  • Cook DJ, Bailey I, Strauss HW, Rouleau J, Wagner HN, Jr, Pitt B (1976) Thallium-201 for myocardial imaging: Appearance of the normal heart. J Nucl Med 17:583–589

    Google Scholar 

  • Gelbart A, Doherty PW, McLaughlin PR, Harrison DC (1976) Na+, K+-ATPase and coronary blood flow as determinants or thallium-201 uptake by ischemic myocardium. Circulation 54:II-70

    Google Scholar 

  • Gould KL (1976) Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilatation. I. Physiological basis and experimental validation. Am J Cardiol 41:267–278

    Google Scholar 

  • Kasalický J (1977) Changes of regional myocardial blood flow during and after acute focal experimental ischaemia. Physiol Bohemoslov 26:373–378

    Google Scholar 

  • Kasalický J, Ressl J, Urbanová D, Widimský J, Ošťádal B, Pelouch V, Vizek M, Procházka J (1977) Relative organ blood flow in rats exposed to intermittent high altitude hypoxia. Pflügers Arch 368:111–115

    Google Scholar 

  • Korb G (1970) Fluorescence microscopy in the diagnosis of experimental myocardial injuries. J Mol Cell Cardiol 1:183–187

    Google Scholar 

  • L'Abbate A, Biagini A, Michelassi C, Maseri A (1979) Myocardial kinetics of thallium and potassium in man. Circulation 60:776–785

    Google Scholar 

  • Lebowitz E, Greene MW, Bradley-Moore P, Atkins H, Ansari A, Richards P, Beigrave E (1973) 201Tl for medical use. J Nucl Med 14:421–422

    Google Scholar 

  • Leppo J, Rosenkrantz J, Rosenthal R, Bontemps R, Yipintsoi T (1981) Quantitative thallium-201 redistribution with a fixed coronary stenosis in dogs. Circulation 63:632–639

    Google Scholar 

  • McLaughlin PR, Martin RP, Doherty P, Daspit S, Goris M, Haskell W, Lewis S, Kriss JP, Harrison DC (1977) Reproducibility of thallium-201 myocardial imaging. Circulation 55:497–503

    Google Scholar 

  • Nishiyama H, Sodd VJ, Adolph RJ, Saenger EL, Lewis JT, Gabel M (1976) Intercomparison of myocardial imaging agents: 201Tl, 129Cs, 43K and 81Rb. J Nucl Med 17:880–889

    Google Scholar 

  • Pohost GM, Okada RD, O'Keefe DD, Gewirtz H, Beller G, Strauss HW, Chaffin JS, Leppo J, Daggett WM (1981) Thallium rediatribution in dogs with severe coronary artery stenosis of fixed caliber. Circ Res 48:439–446

    Google Scholar 

  • Schelbert HR, Schuler G, Ashburn WL, Covell JW (1979) Timecourse of “redistribution” of thallium-201 administered during transient ischemia. Eur J Nucl Med 4:351–358

    Google Scholar 

  • Selye H, Bajusz E, Grasso S, Mendell P (1960) Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology 11:398–407

    Google Scholar 

  • Strauer BE, Buerger S, Buell U (1978) Multifactorial determination of 201Thallium uptake of the heart: An experimental study concerning the influence of ventricular mass, perfusion and oxygen consumption. Basic Res Cardiol 73:298–306

    Google Scholar 

  • Weich HF, Strauss HW, Pitt B (1976) Myocardial extraction fraction of thallium-201. Circulation 54:II-218

    Google Scholar 

  • Weich HF, Strauss HW, Pitt B (1977) The extraction of thallium-201 by the myocardium. Circulation 56:188–191

    Google Scholar 

  • Zaret BL, Strauss HW, Martin ND, Wells SH, Flamm MD (1973) Noninvasive regional myocardial perfusion with radiactive potassium: Study of patients at rest, with exercise, and during angina pectoris. N Engl J Med 288:809–812

    Google Scholar 

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Affiliations

  1. Cardiovascular Research Centre, Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia

    J. Kasalický, O. Mrhová & V. Štýs

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  1. J. Kasalický
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  2. O. Mrhová
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  3. V. Štýs
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Kasalický, J., Mrhová, O. & Štýs, V. Experimental regional myocardial ischaemia and myocardial uptake of potassium analogues; Intercomparison of 42K, 86Rb and 201Tl. Eur J Nucl Med 8, 288–291 (1983). https://doi.org/10.1007/BF00253753

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  • DOI: https://doi.org/10.1007/BF00253753

Keywords

  • Potassium
  • Coronary Artery
  • Radionuclide
  • Nuclear Medicine
  • Myocardial Ischaemia