Summary
Genetically diabetic mice (C57 BLKsJ db/ db) aged 5–6 weeks were given a diet containing 20% by weight of non-nutritive bulk and compared with age matched control diabetic mice on a normal diet (fibre content 4.5%) and non-diabetic mice. The duration of study was 12 weeks. No adverse effects were observed in animals given the high fibre diet. Total food consumption was greater in mice receiving the fibre enriched diet, but their absolute caloric intake was 6% less than control diabetic mice. Both groups exhibited similar rates of growth and development. Water intake in the experimental diabetic mice was reduced and similar to that of normal non-diabetic mice. Fasting blood glucose was significantly decreased in the experimental diabetic mice at 12 weeks. Renal pathological lesions in the control diabetic mice showed glomerular mesangial expansion and deposition of immunoglobulins within the mesangium. The experimental diabetic animals exhibited significantly less renal pathology, including light and immunofluorescent lesions. It is concluded that addition of non-absorbable fibre to the diet of genetically diabetic mice improves glycaemic control and retards the development of diabetic nephropathy.
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Coleman DL, Hummel KP (1966) Studies with the mutation, diabetes, in the mouse. Diabetologia 3:238–248
Sol AH, Kohn CR, Neville DM, Roth J (1975) Insulin receptor deficiency in genetic and acquired obesity. J Clin Invest 56:769–780
Lee SM, Bressler R (1981) Prevention of diabetic nephropathy by diet control in the db/db mouse. Diabetes 30:106–111
Lee SM, Graham A (1980) Early immunopathologic events in experimental diabetic nephropathy: A study in db/db mice. Exp Mol Path 33:323–332
Siegel S (1956) Non-parametric statistics for the behavioral sciences. McGraw-Hill, New York, pp 95–156
Jenkins DJA, Goff DV, Leeds AR, Alberti KGMM, Woliver TMS, Gassull MA, Hockaday TDR (1976) Unabsorbable carbohydrates and diabetes: decreased post-prandial hyperglycaemia. Lancet 2:172–174
Kay RM, Grobin W, Track NS (1981) Diets rich in natural fibre improve carbohydrate tolerance in maturity-onset-non-insulin dependent diabetics. Diabetologia 20:18–21
Kiehm G, Anderson JW, Ward K (1976) Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men. Am J Clin Nutr 29:895–899
Baetens D, Stefan Y, Ravazzola M, Malaisse-Sagal F, Coleman DL, Orci L (1978) Alterations of islet cell populations in spontaneously diabetic mice. Diabetes 27:1 -7
Trayburn P (1979) Thermoregulation in the diabetic-obese (db/ db) mouse. Pfluegers Arch 380:227–232
Wyse BM, Dulin WE (1970) The influence of age and dietary conditions on diabetes in the db/db mouse. Diabetologia 6:268–273
Rasch R (1979) Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. Diabetologia 17:243–248
Mauer SM, Steffes MW, Sutherland DER, Najarian JS, Michael AF, Brown DM (1974) Studies of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic islet transplantation. Diabetes 24:280–285
Haber GB, Heaton KW, Murphy D (1977) Depletion and disruption of dietary fibre. Effects on satiety, plasma glucose and serum insulin. Lancet 2:679–682
Caspary WF, Eisenhaus B, Sufke U, Ptok M, Blume R, Lambcke B, Creutzfeldt W (1980) Effect of dietary fiber on absorption and motility. Front Horm Res 7:202–217
Jenkins DJA, Wolever TMS, Leeds AR, Gassull MA, Haisman P, Dilwari J, Goff DV, Metz GL, Alberti KGMM (1978) Dietary fibres, fibre analogues, and glucose tolerance: Importance of viscosity. Br Med J 1:1392–1394
Gartner K (1978) Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice. Diabetologia 15:59–63
Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM (1981) Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am J Physiol 241:85–94
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Lee, S.M. The effect of a high fibre diet on diabetic nephropathy in the db/db mouse. Diabetologia 22, 349–353 (1982). https://doi.org/10.1007/BF00253580
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DOI: https://doi.org/10.1007/BF00253580