Summary
The occurrence and progression of retinopathy were related to the mean blood glucose levels and the serum concentrations of prolactin, human placental lactogen, oestradiol and progesterone in 57 pregnant insulin-dependent diabetic patients. Fifteen patients had frank retinopathy, of whom eight showed a marked increase in retinopathy. The initial blood glucose levels were significantly higher in patients whose retinopathy progressed, whereas during the second and third trimester similar blood glucose levels were achieved in all groups. Serum concentrations of progesterone and human placental lactogen were significantly increased in diabetic patients during the last trimester when compared with those in normal pregnancies, and during the second trimester, patients with retinopathy showed significantly higher concentrations than those without, but no significant difference was found in oestradiol values. The eight patients with progressive retinopathy showed progesterone, human placental lactogen and oestradiol levels at or above the upper limit of the normal range. Throughout gestation, serum prolactin concentrations were significantly lower in diabetic patients than in healthy subjects. No correlation was found between serum prolactin values and the occurrence of retinopathy.
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Beetham WP (1950) Diabetic retinopathy in pregnancy. Trans Am Ophthalmol Soc 48:205–216
Benirschke K, Driscoll SG (1967) In: Strauss F, Benirschke K, Driscoll SG (eds) Placenta. Springer, Berlin Heidelberg New York, p 553
Cassar J, Kohner EM, Hamilton AM, Gordon H, Joplin GF (1978) Diabetic retinopathy and pregnancy. Diabetologia 15:105–111
De Hertog R, Thomas K, Hoet JJ, Vanderheyden I (1976) Plasma concentrations of unconjugated oestrone, oestradiol-17β and oestradiol, and HCS throughout pregnancy in diabetics and gestational diabetics. Diabetologia 12:455–461
Freinkel N (1980) Of pregnancy and progeny. Diabetes 29: 1023–1035
Frøland A, Hagen C, Lauritzen E (1977) Diabetic retinopathy and prolactin. Lancet 1:45
Harter M, Balarac N, Pourcher Ph, Koslowski JM, Krebs B, Ramaioli A (1976) Diabetic retinopathy and proiactin. Lancet 2:961–962
Herrera L (1958) The precision of percentiles in establishing normal limits in medicine. J Lab Clin Med 52:34–42
Hunter PR, Anderson J, Lunn TA, Horrobin DF, Boyns AR, Cole EN (1974) Diabetic retinopathy and prolactin. Lancet 1:1237
Janert H, Mohnike G, Georgi P (1957) Ophthalmologische Diabetesstudien III. Retinopathia proliferans und Iridopathie. Klin Wochenschr 35:110–119
Jervell J, Moe N, Skjaeraasen J, Blystad W, Egge K (1979) Diabetes mellitus and pregnancy. Management and results at Rikshospitalet, Oslo 1970–1977. Diabetologia 16:151–155
Jänne O, Apter D, Vihko R (1974) Assay of testosterone, progesterone and 17α-hydroxyprogesterone in human plasma by radioimmunoassay after separation on hydroxyalkoxypropyl Sephadex. J Steroid Biochem 5:155–162
Lindberg BS, Lindberg P, Martinsson K, Johansson EDB (1974) Oestrogens during pregnancy I. Radioimmunological methods for the estimation of oestrone, oestradiol-17β, and oestriol in pregnancy plasma. Acta Obstet Gynecol Scand (Suppl) 32:5–19
Sadovsky E, Weinstein D, Ben-David M, Polishuk WZ (1977) Serum prolactin in normal and pathologic pregnancy. Obstet Gynecol 50:559–561
Selenkow HA, Varma K, Younger D, White P, Emerson K (1971) Patterns of serum immunoreactive human placental lactogen (IR-HPL) and chorionic gonadotropin (IR-HCG) in diabetic pregnancy. Diabetes 20:696–706
Seppälä M, Hirvonen E, Ranta T, Virkkunen P, Leppäluoto J (1975) Raised serum prolactin levels in amenorrhoea. Br Med J 2:305–306
Spellacy WN, Conly PW, Cleveland WW, Buhi WL (1975) Effects of fetal sex and weight and placental weight on maternal serum progesterone and chorionic gonadotropin concentrations. Am J Obstet Gynecol 122:278–282
Tyson JE, Hwang P, Guyda H, Friesen HG (1972) Studies on prolactin secretion in human pregnancy. Am J Obstet Gynecol 113:14–20
Williamson JR, Kilo C (1980) Vascular complications in diabetes mellitus. N Engl J Med 302:399–400
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Larinkari, J., Laatikainen, L., Ranta, T. et al. Metabolic control and serum hormone levels in relation to retinopathy in diabetic pregnancy. Diabetologia 22, 327–332 (1982). https://doi.org/10.1007/BF00253576
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DOI: https://doi.org/10.1007/BF00253576