Abstract
Regional distribution of pulmonary ventilation and perfusion has been determined of 13 patients with chronic obstructive pulmonary disease (COPD). Eight patients had alpha1-antitrypsin deficiency (α1ATD). Ventilation studies were carried out using xenon-133 (133Xe) and krypton-81m (81mKr) gases. Trapping indices were determined from the wash-out part of the xenon ventilation studies.
Results obtained from patients were compared with those of normal controls. Ventilation studies with 81mKr showed pulmonary changes more clearly than did 133Xe studies and the trapping of radio-xenon was more extensive in lung bases than in apices whether or not the patients had α1ATD. The distribution of perfusion followed a pattern similar to that of ventilation, but did not differ statistically from that of the normal controls.
This is a preview of subscription content, log in via an institution to check access.
Access this article
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
Similar content being viewed by others
References
Fallat R, Powell M, Kueppers F, Nadel J, Murray J (1971) Chronic obstructive pulmonary disease with intermediate alpha1-antitrypsin deficiency. Chest 59:20S-22S
Fallat RJ, Powell MR, Kueppers F, Lilker E (1973) 133Xe ventilation studies in α1-antitrypsin deficiency. J Nucl Med 14:5–13
Fremlin JH, Stammers K, Stewart FR (1978) A new generator for krypton-81m. Nucl Instrum Meth 156:369–373
Heckscher T, Bass H, Oriol A, Rose B, Anthonisen NR, Bates DV (1968) Regional lung function in patients with broncial asthma. J Clin Invest 47:1063–1070
Jones T, Clark JC, Hughes JM, Rosenzweig DY (1970) 81mKr generator and its uses in cardiopulmonary studies with scintillation camera. J Nucl Med 11:118–1243
Kanner RE, Klauber MR, Watanabe S, Renzetti AD, Bigler A (1973) Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha1-antitrypsin. Am J Med 54:706–772
Laurell CB, Eriksson S (1963) The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. Scan J Clin Invest 15:132–149
Mittman C, Lieberman J, Marasso F, Miranda A (1971) Smoking and chronic obstructive lung disease in alpha1-antitrypsin deficiency. Chest 60:214–221
MRC (1965) Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet 1, 775
Schor RA, Shames DM, Weber PM, Dos Remedios LV (1978) Regional ventilation studies with 81mKr and 133Xe: A comparative analysis. J Nucl Med 19:349–353
Secker-Walker RH, Hill RI, Markham J, Baker J, Wilhelm J, Alderson PO, Potchen EJ (1973) The measurement of regional ventilation in man: A new method of quantitation. J Nucl Med 14:725–732
Stevens PM, Hnilica VS, Johnson PC, Bell RL (1971) Pathophysiology of hereditary emphysema. Ann Intern Med 74:672–680
Stockley RA (1979) Alpha1-antitrypsin phenotypes in cor pulmonale due to chronic obstructive airways disease. Q J Med 48:419–428
Susskind H, Atkins HL, Goldman AG, Acevedo JC, Pate HR, Richards P, Brill AB (1981) Sensitivity of 81mKr and 127Xe in evaluating nonembolic pulmonary disease. J Nucl Med 22:781–786
Welch MH, Richardson RH, Whitcomb WH, Hammarsten JF, Guenter CA (1969) The lung scan in alpha1-antitrypsin deficiency. J Nucl Med 10:687–690
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mostafa, A.B.M.G., Tulley, N.J., Harding, L.K. et al. Regional distribution of ventilation and perfusion in patients with obstructive pulmonary disease and alpha1-antitrypsin deficiency. Eur J Nucl Med 8, 338–341 (1983). https://doi.org/10.1007/BF00253541
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00253541