Abstract
A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-l-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio; 11.4). The second highest uptake was of 11C-aminocyclopentane-carboxylic acid (ACPC). The newly synthesized 11C-dl-methyl-ACPC characteristically showed higher accumulation in tumor than in liver and the tumor to liver ratio reached 3.0 at 60 min after injection. It is suggested that 11C-l-methionine and 11C-dl-methyl-ACPC are useful amino acids for the diagnosis of cancer using positron emission tomography.
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This work was supported by a Grant-in-Aid for Scientific Research No. 00544052, Ministry of Education, Science and Culture, Japan
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Kubota, K., Yamada, K., Fukada, H. et al. Tumor detection with carbon-11-labelled amino acids. Eur J Nucl Med 9, 136–140 (1984). https://doi.org/10.1007/BF00253516
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DOI: https://doi.org/10.1007/BF00253516