Abstract
Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4 − and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.
Similar content being viewed by others
References
Arima, M., Yokoi, H., Sonoda, T.: Preoperative identification of tumour of the parathyroid by ultrasonotomography. Surg. Gynecol. Obstet. 141, 242–244 (1975)
Burckhardt, P., Bischof-Delaloye, A., Ruedi, B.: Pre-operative localization of hyperfunctioning parathyroid tissue by parathyroid scintigraphy. Acta Endocrinol. 81, 298–309 (1976)
Doppman, J.L., Malette, L.E., Marx, J.S.: The localization of abnormal mediastinal parathyroid glands. Radiology 115, 31–36 (1975)
Normann, E., Bøhmer, T., Otnes, B.: Clinical radionuclide-imaging of enlarged parathyroids with 131I-labelled toluidine blue. Acta Chir. Scand. 140, 517–522 (1974)
Normann, E., Rootwelt, K., Solheim, D., Sødal, G.: Use of 131I-toluidine blue in radionuclide imaging of enlarged parathyroid glands. Ann. Chir. Gyn. 65, 249–252 (1976)
Potchen, E.J., Watts, H.G., Awwad, H.K.: Parathyroid scintiscanning. Radiol. Clin. North. Am. 5, 267–275 (1967)
Reitz, R.E., Pollard, J.J., Wang, C.A.: Localization of parathyroid adenomas by selective venous catheterization and radioimmuno-assay. N. Engl. J. Med. 281, 348–351 (1969)
Samuels, B.I., Dowdy, A.H., Lecky, J.W.: Parathyroid thermography. Radiology 104, 575–578 (1972)
Samuels, B.I.: The present status of parathyroid thermography. JAMA 233, 907–908 (1975)
Skretting, A., Aas, M.: A Computer Algorithm for triple radionuclide subtraction studies applied for preoperative localization of enlarged parathyroid glands. Eur. J. Nucl. Med. 2, 239–245 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Skretting, A., Aas, M., Normann, E. et al. Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands. Eur J Nucl Med 3, 5–9 (1978). https://doi.org/10.1007/BF00253470
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00253470