Abstract
We have undertaken gallium imaging studies in 49 patients with histologically proven small cell lung cancer. Tracer uptake in the primary tumour was seen in 98% of cases. Twenty five patients underwent repeat scanning after induction chemotherapy and a correlation was demonstrated between conventional parameters of response and gallium scan changes (P<0.01). There was no correlation between initial gallium activity and subsequent chemoresponse (which was evaluated in 32 patients) or survival (measured in 42 patients). Ten patients who had shown a complete response to induction treatment were followed up with gallium scans repeated at three monthly intervals. Such longitudinal studies were particularly helpful in excluding tumour activity when the appearance of the chest radiographs were difficult to interpret.
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References
Bekerman C, Hoffer PB, Bitran JD (1984) The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med 14:296–323
Bidani N, Moohr JW, Kirchner P, Peng E, Bekerman C, Cooper M (1978) Gallium scanning as prognostic indicator in neuroblastoma. J Nucl Med 19:692 (abstr.)
Bitran JD, DeMeester TR, Rezai-Zadeh K, Toledo-Pereyra LH, Churg A, Golomb HM (1978) Clinicopathologic correlations demonstrating the failure of 67 gallium scanning in determining response to radiotherapy. Chest 73:356–359
Bitran JD, Bekerman C, Pisnky S (1981) Sequential scintigraphic staging of small cell carcinoma. Cancer 47:1971–1975
Bradley WP, Alderson PO, Eckelman WC, Hamilton RG, Weiss JF (1978) Decreased tumour uptake of gallium-67 in animals after whole-body irradiation. J Nucl Med 19:204–209
Brereton HD, Line BR, Londer HN, O'Donnell JF, Kent H, Johnson RE (1978) Gallium scans for staging small cell lung cancer. JAMA 240:666–667
Dorward AJ, Banham SW, Hutcheon AW, Ahmedzai S, Cunningham D, Gregor A, Soukop M, Stack BHR, Mackay NSD, Kaye SB (1986) Short duration combination chemotherapy in the treatment of small cell lung cancer. Thorax 41:688–691
Henkin RE, Polcyn RE, Quinn JL (1974) Scanning treated Hodgkin's disease with 67 ga citrate. Radiology 110:151–154
Higashi T, Wakao H, Nakamura K, Shimura A, Yokoyama T, Suzuki S, Watanabe K, Kruglik GD (1980) Quantitative gallium-67 scanning for predictive value in primary lung carcinoma. J Nucl Med 21:628–632
Higashi T, Nakamura K, Suzuki S, Allison JR, Wakao H (1982) Ga-67 scan as a prognostic indicator in primary lung carcinoma. Clin Nucl Med 7:553–557
Patterson AHG, McReady VR (1975) The current status of gallium-67 scanning. Br J Radiol 48:944 (abstr.)
SridharKS, ChandarlapatySKC, FernandezL, DonnellyE, CairnsV (1985) Prognostic Significance of gallium (Ga) scanning in small cell lung cancer (SCLC). In: Gamsu G, Sanders D, (Chairpersons) IV World Conference on Lung Cancer. Toronto IASLC, 95 (abstr.)
Van der Schoot JB, Groen AS, De Jong J (1972) Gallium-67 scintigraphy in lung diseases. Thorax 27:543–546
Yang SL, Alderson PO, Kaizer HA, Wagner HN (1979) Serial Ga-67 citrate imaging in children with neoplastic diease: Concise communication. J Nucl Med 20:210–214
Yeh SDJ, Benua RS, Tan CTC (1979) Gallium scan in recurrent Hodgkin's disease in children. Clin Nucl Med 4:359–367
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Milroy, R., McKillop, J., Smith, L. et al. Gallium scintigraphy in small cell lung cancer. Eur J Nucl Med 14, 57–59 (1988). https://doi.org/10.1007/BF00253441
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DOI: https://doi.org/10.1007/BF00253441