Abstract
Follow-up studies have been undertaken on patients with carcinoma of the prostate who, prior to treatment, exhibited uniformly increased bone uptake of 99mTclabelled methylene diphosphonate. In general, therapy led to a reduction in the degree of radiopharmaceutical uptake on follow-up. In some cases the radionuclide bone images retained their uniform appearances, whilst in others a patchy uptake developed, more characteristic of metastatic deposits. Radiographically the changes were less pronounced than those seen in the radionuclide studies.
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Perkins, A.C., Hardy, J.G., Wastie, M.L. et al. Serial radionuclide imaging during treatment of patients with diffuse bone metastases from carcinoma of the prostate. Eur J Nucl Med 7, 322–323 (1982). https://doi.org/10.1007/BF00253429
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DOI: https://doi.org/10.1007/BF00253429