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Stannous ion quantitation in 99mTc-radiopharmaceutical kits

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Abstract

A simple and inexpensive method for the estimation of stannous ion, Sn (II), in radiopharmaceutical kits is described. The method used is a potentiometric titration of Sn (II) in 1 N HCl medium, using potassium iodate as the oxidizing agent in an atmosphere of nitrogen. The apparatus includes a pH meter, a platinum electrode, and a simple titration cell. Several commonly used radiopharmaceutical kits were analyzed for their Sn (II) content using this method. These studies indicate that the procedure can be used, as a routine quantitative test for the Sn (II) content of various 99mTc-labeled radiopharmaceuticals.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, N.Y., USA

    L. R. Chervu, B. Vallabhajosyula, J. Mani, S. B. Chun & M. D. Blaufox

Authors
  1. L. R. Chervu
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  2. B. Vallabhajosyula
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  3. J. Mani
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  4. S. B. Chun
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  5. M. D. Blaufox
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Chervu, L.R., Vallabhajosyula, B., Mani, J. et al. Stannous ion quantitation in 99mTc-radiopharmaceutical kits. Eur J Nucl Med 7, 291–293 (1982). https://doi.org/10.1007/BF00253422

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  • DOI: https://doi.org/10.1007/BF00253422

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